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ATXN1 elisa kit :: Rat Ataxin 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS007102 ATXN1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ataxin 1 (ATXN1), ELISA Kit

 Also Known As   

Rat Ataxin 1 ELISA Kit

 Product Gene Name   

ATXN1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 6; NC_000006.11 (16299343..16761721, complement). Location: 6p23
 OMIM    164400
 3D Structure    ModBase 3D Structure for P54253
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 Species Reactivity    Rat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ATXN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ATXN1 purchase    MBS007102 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ataxin 1 (ATXN1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATXN1. The ELISA analytical biochemical technique of the MBS007102 kit is based on ATXN1 antibody-ATXN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATXN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATXN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ATXN1. It may not necessarily be applicable to this product.
 NCBI GI #    189491748
 NCBI GeneID    6310
 NCBI Accession #    NP_001121636.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001128164.1 [Other Products]
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 UniProt Primary Accession #    P54253 [Other Products]
 UniProt Secondary Accession #    Q17S02; Q9UJG2; Q9Y4J1 [Other Products]
 UniProt Related Accession #    P54253 [Other Products]
 Molecular Weight    86,923 Da
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 NCBI Official Full Name    ataxin-1
 NCBI Official Synonym Full Names    ataxin 1
 NCBI Official Symbol    ATXN1 [Similar Products]
 NCBI Official Synonym Symbols   
ATX1; SCA1; D6S504E
[Similar Products]
 NCBI Protein Information    ataxin-1; spinocerebellar ataxia type 1 protein
 UniProt Protein Name    Ataxin-1
 UniProt Synonym Protein Names   
Spinocerebellar ataxia type 1 protein
 Protein Family    Ataxin
 UniProt Gene Name    ATXN1 [Similar Products]
 UniProt Synonym Gene Names    ATX1; SCA1 [Similar Products]
 UniProt Entry Name    ATX1_HUMAN
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 NCBI Summary for ATXN1    The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]
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 UniProt Comments for ATXN1    ataxin-1: spinocerebellar ataxia type 1 (SCA1) protein. Expansion of CAG repeats in the SCA1 gene results in an abnormally long polyglutamine tract in the protein, causing polyglutamine-induced neurodegeneration. 14-3-3 and Akt kinase stabilize both wild-type and mutant forms of ataxin-1. The expansion of the polyglutamine tract may alter this function.

Protein type: RNA-binding; Nuclear export

Chromosomal Location of Human Ortholog: 6p23

Cellular Component: nucleoplasm; nuclear RNA export factor complex; nuclear matrix; intracellular membrane-bound organelle; cytoplasm; nucleus; nuclear inclusion body

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; DNA binding; protein self-association; poly(U) binding; chromatin binding; poly(rG) binding

Biological Process: RNA processing; transcription, DNA-dependent; adult locomotory behavior; nuclear export; negative regulation of insulin-like growth factor receptor signaling pathway; visual learning; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; regulation of excitatory postsynaptic membrane potential; negative regulation of transcription, DNA-dependent; alveolus development

Disease: Spinocerebellar Ataxia 1
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 Research Articles on ATXN1    1. Patients carrying JARID2 deletion manifested with cognitive impairment, gait disturbance and a characteristic facial appearance, whereas patients with deletion of ATXN1 seemed to be characterized by intellectual disability and behavioural abnormalities
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATXN1 elisa kitDiseases associated with ATXN1 elisa kit
 Reference Product  PubMed Publications
 ATXN2 elisa kit  >6 publications with ATXN1 and ATXN2
 RBM17 elisa kit  >2 publications with ATXN1 and RBM17
 ANP32A elisa kit  >1 publications with ATXN1 and ANP32A
 COIL elisa kit  >1 publications with ATXN1 and COIL
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >34 publications with ATXN1 and Brain Diseases
 Nervous System Diseases Antibodies  >34 publications with ATXN1 and Nervous System Diseases
 Spinocerebellar Ataxias Antibodies  >31 publications with ATXN1 and Spinocerebellar Ataxias
 Disease Models, Animal Antibodies  >9 publications with ATXN1 and Disease Models, Animal
 Nerve Degeneration Antibodies  >3 publications with ATXN1 and Nerve Degeneration
 Drug Toxicity Antibodies  >3 publications with ATXN1 and Drug Toxicity
 Movement Disorders Antibodies  >2 publications with ATXN1 and Movement Disorders
 Neoplasms Antibodies  >2 publications with ATXN1 and Neoplasms
 Heart Defects, Congenital Antibodies  >2 publications with ATXN1 and Heart Defects, Congenital
 Immune System Diseases Antibodies  >2 publications with ATXN1 and Immune System Diseases
Organs/Tissues associated with ATXN1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >41 publications with ATXN1 and Nerve
 Brain Antibodies  >28 publications with ATXN1 and Brain
 Heart Antibodies  >3 publications with ATXN1 and Heart
 Blood Antibodies  >3 publications with ATXN1 and Blood
 Embryonic Tissue Antibodies  >3 publications with ATXN1 and Embryonic Tissue
 Eye Antibodies  >3 publications with ATXN1 and Eye
 Muscle Antibodies  >2 publications with ATXN1 and Muscle
 Vascular Antibodies  >2 publications with ATXN1 and Vascular
 Ovary Antibodies  >1 publications with ATXN1 and Ovary
 Umbilical Cord Antibodies  >1 publications with ATXN1 and Umbilical Cord
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