AAA35529.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,708 Da
NCBI Official Full Name
atrial natriuretic peptide
NCBI Official Synonym Full Names
natriuretic peptide A
NCBI Official Synonym Symbols
ANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF [Similar Products]
NCBI Protein Information
natriuretic peptides A
UniProt Protein Name
Natriuretic peptides A
UniProt Synonym Protein Names
CDD-ANF; Cardiodilatin; CDD
UniProt Synonym Gene Names
UniProt Entry Name
ANF_HUMAN
NCBI Summary for ANP
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]
UniProt Comments for ANP
NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.
Protein type: Secreted; Hormone; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: extracellular region; extracellular space; mast cell granule; nucleus; perinuclear region of cytoplasm
Molecular Function: neuropeptide hormone activity; peptide hormone receptor binding; protein binding; receptor binding
Biological Process: cardiac muscle hypertrophy; cellular protein metabolic process; cGMP biosynthetic process; female pregnancy; gene expression; negative regulation of cell growth; negative regulation of systemic arterial blood pressure; neuropeptide signaling pathway; positive regulation of heart rate; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of blood vessel size; response to hypoxia; response to insulin stimulus; transcription initiation from RNA polymerase II promoter
Disease: Atrial Fibrillation, Familial, 6; Atrial Standstill 2
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Products associated with ANP elisa kit
Pathways associated with ANP elisa kit
Diseases associated with ANP elisa kit
Organs/Tissues associated with ANP elisa kit
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