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BECN1 elisa kit :: Rat Beclin 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2533549
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Beclin 1 (BECN1), ELISA Kit

★Popular Item★
 Also Known As   

Rat BECN1 (Beclin 1) ELISA Kit 

 Product Gene Name   

BECN1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    604378
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 Species Reactivity    Rat
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 Specificity    This kit recognizes natural and recombinantRatBECN1. No significant cross-reactivity or interference between RatBECN1 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BECN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BECN1 purchase    MBS2533549 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Beclin 1 (BECN1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing BECN1, with an estimated sensitivity of Min: 0.094ng/mL; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2533549 kit is based on BECN1 antibody-BECN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BECN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BECN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for BECN1 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of RatBECN1concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to BECN1. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for BECN1and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain BECN1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of BECN1.You can calculate the concentration of BECN1in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of BECN1 elisa kit    BECN1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2533549. Click to request current manual
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NCBI/Uniprot data below describe general gene information for BECN1. It may not necessarily be applicable to this product.
 NCBI GI #    4680381
 NCBI GeneID    8678
 NCBI Accession #    AAD27650.1 [Other Products]
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 UniProt Secondary Accession #    O75595; Q9UNA8; B2R6N7 [Other Products]
 UniProt Related Accession #    Q14457 [Other Products]
 Molecular Weight    51,896 Da
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 NCBI Official Full Name    beclin 1
 NCBI Official Synonym Full Names    beclin 1, autophagy related
 NCBI Official Symbol    BECN1 [Similar Products]
 NCBI Official Synonym Symbols   
ATG6; VPS30; beclin1
[Similar Products]
 NCBI Protein Information    beclin-1
 UniProt Protein Name    Beclin-1
 UniProt Synonym Protein Names   
Coiled-coil myosin-like BCL2-interacting protein; Protein GT197
 Protein Family    Beclin
 UniProt Gene Name    BECN1 [Similar Products]
 UniProt Synonym Gene Names    GT197 [Similar Products]
 UniProt Entry Name    BECN1_HUMAN
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 NCBI Summary for BECN1    This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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 UniProt Comments for BECN1    beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Protein type: Membrane protein, peripheral; Autophagy; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: autophagic vacuole; cytoplasmic membrane-bound vesicle; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; endosome membrane; extrinsic to membrane; mitochondrial membrane; mitochondrion; nucleus; phagocytic vesicle; trans-Golgi network

Molecular Function: phosphoinositide 3-kinase binding; protein binding; ubiquitin protein ligase binding

Biological Process: apoptosis; autophagic vacuole formation; autophagy; beta-amyloid metabolic process; cellular defense response; cellular response to glucose starvation; cellular response to nitrogen starvation; CVT pathway; cytokinesis; defense response to virus; engulfment of apoptotic cell; late endosome to vacuole transport; lysosome organization and biogenesis; macroautophagy; mitotic metaphase plate congression; negative regulation of apoptosis; negative regulation of cell proliferation; neuron development; positive regulation of autophagy; positive regulation of phosphoinositide 3-kinase cascade; receptor catabolic process; regulation of catalytic activity; regulation of cytokinesis; response to drug; response to hypoxia; response to vitamin E; viral reproduction
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 Research Articles on BECN1    1. These results demonstrate the essential role of BECN1 in the functional formation of autophagosomes, but not in LC3B lipidation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BECN1 elisa kitPathways associated with BECN1 elisa kit
 Reference Product  PubMed Publications
 BCL2 elisa kit  >73 publications with BECN1 and BCL2
 BCL2L1 elisa kit  >64 publications with BECN1 and BCL2L1
 UVRAG elisa kit  >46 publications with BECN1 and UVRAG
 ATG14 elisa kit  >33 publications with BECN1 and ATG14
 AMBRA1 elisa kit  >28 publications with BECN1 and AMBRA1
 PIK3C3 elisa kit  >26 publications with BECN1 and PIK3C3
 PARK2 elisa kit  >18 publications with BECN1 and PARK2
 MCL1 elisa kit  >17 publications with BECN1 and MCL1
 PIK3R4 elisa kit  >12 publications with BECN1 and PIK3R4
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Macroautophagy Pathway antibodies  Macroautophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with BECN1 elisa kitOrgans/Tissues associated with BECN1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >171 publications with BECN1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >118 publications with BECN1 and Cardiovascular Diseases
 Necrosis Antibodies  >97 publications with BECN1 and Necrosis
 Disease Models, Animal Antibodies  >97 publications with BECN1 and Disease Models, Animal
 Liver Diseases Antibodies  >71 publications with BECN1 and Liver Diseases
 Liver Neoplasms Antibodies  >65 publications with BECN1 and Liver Neoplasms
 Inflammation Antibodies  >61 publications with BECN1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >60 publications with BECN1 and Carcinoma, Hepatocellular
 Lung Diseases Antibodies  >55 publications with BECN1 and Lung Diseases
 Heart Diseases Antibodies  >51 publications with BECN1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >178 publications with BECN1 and Brain
 Blood Antibodies  >123 publications with BECN1 and Blood
 Liver Antibodies  >104 publications with BECN1 and Liver
 Muscle Antibodies  >95 publications with BECN1 and Muscle
 Heart Antibodies  >85 publications with BECN1 and Heart
 Lung Antibodies  >75 publications with BECN1 and Lung
 Vascular Antibodies  >63 publications with BECN1 and Vascular
 Nerve Antibodies  >45 publications with BECN1 and Nerve
 Kidney Antibodies  >44 publications with BECN1 and Kidney
 Lymph Antibodies  >34 publications with BECN1 and Lymph
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