Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow ELISA Kit rightarrow ROS1 rightarrow Rat ROS1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • embryonic ectoderm development (EED) Antibody
 • Lipid Peroxide (LPO) ELISA Kit
 • ATPase, Cu++ Transporting Beta Polypeptide (ATP7b) ELISA Kit
 • thymus-leukemia antigen (Tla) ELISA Kit
 • Flt3 Antibody
 • MACC1 Antibody
 • IgG Secondary Antibody
 • Vinculin (VCL) ELISA Kit
 • OATP (SLCO1A2) Antibody
 • Growth Arrest Specific Protein 6 (GAS6) ELISA Kit
 • Neutralite Avidin Antibody
 • CRP - C-Reactive Protein Antibody
 • Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Antibody
 • Hen Egg Lysozyme (HEL) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

ROS1 elisa kit :: Rat C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2021712 (SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells  /  $285 +1 FREE 8GB USB
48-Strip-Wells  /  $530 +1 FREE 8GB USB
96-Strip-Wells  /  $715 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,910 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,280 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1), ELISA Kit

 Also Known As   

C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) ELISA Kit

 Product Synonym Names    MCF3; ROS; c-Ros-1; v-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1
 Product Gene Name   

ROS1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    165020
 3D Structure    ModBase 3D Structure for P08922
Section Bar
 Species Reactivity    Rat
Section Bar
 Specificity    This assay has high sensitivity and excellent specificity for detection of C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1).
No significant cross-reactivity or interference between C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) and analogues was observed.
Section Bar
 Assay Type    Double-antibody Sandwich
 Samples    Serum, Plasma, Tissue homogenates, Cell lysates and Other Biological Fluids
 Detection Range    15.62-1000pg/mL
 Sensitivity    < 6.6pg/mL
 Application    Enzyme-linked immunosorbent assay for Antigen Detection.
 Intra-assay Precision (Precision within an assay)    3 samples with low, middle and high level C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) were tested 20 times on one plate, respectively.
 Inter-assay Precision (Precision between assays)    3 samples with low, middle and high level C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) were tested on 3 different plates, 8 replicates in each plate.
 CV(%) =    SD/meanX100
 Intra-Assay    CV<10%
 Inter-Assay    CV<12%
Section Bar
 Preparation and Storage    The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ROS1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ROS1 purchase    MBS2021712 is a ready-to-use microwell, strip plate Double-antibody Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.62-1000pg/mL in biological research samples containing ROS1, with an estimated sensitivity of < 6.6pg/mL. The ELISA analytical biochemical technique of the MBS2021712 kit is based on ROS1 antibody-ROS1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ROS1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ROS1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Tissue homogenates, Cell lysates and Other Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Table BarTOPTable Bar
 

Related Product Information for ROS1 elisa kit

   The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) in the samples is then determined by comparing the O.D. of the samples to the standard curve.
 Product Categories/Family for ROS1 elisa kit    Tumor immunity
Section Bar
 Typical Testing Data/Standard Curve (for reference only) of ROS1 elisa kit    ROS1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
Table BarTOPTable Bar
Sample Manual Insert of MBS2021712. Click to request current manual
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ROS1. It may not necessarily be applicable to this product.
 NCBI GI #    187252527
 NCBI GeneID    6098
 NCBI Accession #    AAI66687.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P08922 [Other Products]
 UniProt Secondary Accession #    Q15368; Q5TDB5 [Other Products]
 UniProt Related Accession #    P08922 [Other Products]
 Molecular Weight    263,915 Da
Table BarTOPTable Bar
 NCBI Official Full Name    C-ros oncogene 1, receptor tyrosine kinase
 NCBI Official Synonym Full Names    ROS proto-oncogene 1 , receptor tyrosine kinase
 NCBI Official Symbol    ROS1 [Similar Products]
 NCBI Official Synonym Symbols   
ROS; MCF3; c-ros-1
[Similar Products]
 NCBI Protein Information    proto-oncogene tyrosine-protein kinase ROS
 UniProt Protein Name    Proto-oncogene tyrosine-protein kinase ROS
 UniProt Synonym Protein Names   
Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase
 Protein Family    Protein
 UniProt Gene Name    ROS1 [Similar Products]
 UniProt Synonym Gene Names    MCF3; ROS [Similar Products]
 UniProt Entry Name    ROS1_HUMAN
Section Bar
 NCBI Summary for ROS1    This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for ROS1    ROS: a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma.

Protein type: Oncoprotein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; Protein kinase, TK; TK group; Sev family

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding

Biological Process: cell proliferation; peptidyl-tyrosine phosphorylation; spermatogenesis; cell growth; columnar/cuboidal epithelial cell development; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of TOR signaling pathway
Table BarTOPTable Bar
 Research Articles on ROS1    1. Six out of 65 (9%) BTC patients were positive for the FIG-ROS1 fusion, comprising two out of 14 (14%) gallbladder carcinoma (GBC) patients and four out of 25 (16%) extrahepatic cholangiocarcinoma (ECC) patients.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with ROS1 elisa kitDiseases associated with ROS1 elisa kit
 Reference Product  PubMed Publications
 EGFR elisa kit  >94 publications with ROS1 and EGFR
 OR13G1 elisa kit  >3 publications with ROS1 and OR13G1
 TAS2R50 elisa kit  >3 publications with ROS1 and TAS2R50
 PTPN6 elisa kit  >2 publications with ROS1 and PTPN6
 ABL1 elisa kit  >1 publications with ROS1 and ABL1
 PALLD elisa kit  >1 publications with ROS1 and PALLD
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >101 publications with ROS1 and Carcinoma
 Lung Neoplasms Antibodies  >96 publications with ROS1 and Lung Neoplasms
 Carcinoma, Non-Small-Cell Lung Antibodies  >65 publications with ROS1 and Carcinoma, Non-Small-Cell Lung
 Lymphoma Antibodies  >59 publications with ROS1 and Lymphoma
 Carcinoma, Squamous Cell Antibodies  >18 publications with ROS1 and Carcinoma, Squamous Cell
 Glioma Antibodies  >14 publications with ROS1 and Glioma
 Cholangiocarcinoma Antibodies  >13 publications with ROS1 and Cholangiocarcinoma
 Infertility, Male Antibodies  >11 publications with ROS1 and Infertility, Male
 Adenocarcinoma of lung Antibodies  >11 publications with ROS1 and Adenocarcinoma of lung
 Melanoma Antibodies  >7 publications with ROS1 and Melanoma
Organs/Tissues associated with ROS1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >170 publications with ROS1 and Lung
 Brain Antibodies  >19 publications with ROS1 and Brain
 Liver Antibodies  >13 publications with ROS1 and Liver
 Vascular Antibodies  >4 publications with ROS1 and Vascular
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions