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CD163 elisa kit :: Rat CD163 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2516101
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD163, ELISA Kit

★Popular Item★
 Also Known As   

Rat CD163 (Cluster of Differentiation 163) ELISA Kit

 Product Gene Name   

CD163 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2516101 COA    COA PDF
 OMIM    605545
 3D Structure    ModBase 3D Structure for Q86VB7
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 Species Reactivity    Rat
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 Specificity    This kit recognizes natural and recombinantRatCD163. No significant cross-reactivity or interference between RatCD163 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    0.313-20ng/mL
 Sensitivity    0.188ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CD163 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CD163 purchase    MBS2516101 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CD163, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.313-20ng/mL in biological research samples containing CD163, with an estimated sensitivity of 0.188ng/mL. The ELISA analytical biochemical technique of the MBS2516101 kit is based on CD163 antibody-CD163 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CD163 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CD163. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CD163 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of RatCD163concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CD163. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CD163and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CD163, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CD163.You can calculate the concentration of CD163in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CD163 elisa kit    CD163 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2516101. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CD163. It may not necessarily be applicable to this product.
 NCBI GI #    5107945
 NCBI GeneID    9332
 NCBI Accession #    CAB45233.1 [Other Products]
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 UniProt Primary Accession #    Q86VB7 [Other Products]
 UniProt Secondary Accession #    Q07898; Q07899; Q07900; Q07901; Q2VLH7; C9JIG2 [Other Products]
 UniProt Related Accession #    Q86VB7 [Other Products]
 Molecular Weight    124,958 Da
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 NCBI Official Full Name    CD163
 NCBI Official Synonym Full Names    CD163 molecule
 NCBI Official Symbol    CD163 [Similar Products]
 NCBI Official Synonym Symbols   
M130; MM130
[Similar Products]
 NCBI Protein Information    scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen
 UniProt Protein Name    Scavenger receptor cysteine-rich type 1 protein M130
 UniProt Synonym Protein Names   
Hemoglobin scavenger receptor; CD_antigen: CD163Soluble CD163; sCD163
 Protein Family    Scavenger receptor cysteine-rich type 1 protein
 UniProt Gene Name    CD163 [Similar Products]
 UniProt Synonym Gene Names    M130; sCD163 [Similar Products]
 UniProt Entry Name    C163A_HUMAN
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 NCBI Summary for CD163    The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for CD163    CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; acute-phase response
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 Research Articles on CD163    1. This study highlights that active CD and UC are associated with increased macrophage activation, as indicated by elevated sCD163 levels and monocytic CD163 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD163 elisa kitPathways associated with CD163 elisa kit
 Reference Product  PubMed Publications
 CD68 elisa kit  >396 publications with CD163 and CD68
 IL10 elisa kit  >98 publications with CD163 and IL10
 HMOX1 elisa kit  >46 publications with CD163 and HMOX1
 CSF1R elisa kit  >31 publications with CD163 and CSF1R
 IL6 elisa kit  >15 publications with CD163 and IL6
 C1QB elisa kit  >1 publications with CD163 and C1QB
 VSIG4 elisa kit  >1 publications with CD163 and VSIG4
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
Diseases associated with CD163 elisa kitOrgans/Tissues associated with CD163 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >393 publications with CD163 and Inflammation
 Necrosis Antibodies  >176 publications with CD163 and Necrosis
 Cardiovascular Diseases Antibodies  >113 publications with CD163 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >108 publications with CD163 and Nervous System Diseases
 Brain Diseases Antibodies  >67 publications with CD163 and Brain Diseases
 Disease Models, Animal Antibodies  >64 publications with CD163 and Disease Models, Animal
 Fibrosis Antibodies  >60 publications with CD163 and Fibrosis
 Lung Diseases Antibodies  >55 publications with CD163 and Lung Diseases
 Adenocarcinoma Antibodies  >43 publications with CD163 and Adenocarcinoma
 Heart Diseases Antibodies  >37 publications with CD163 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >643 publications with CD163 and Blood
 Vascular Antibodies  >181 publications with CD163 and Vascular
 Skin Antibodies  >120 publications with CD163 and Skin
 Bone Antibodies  >111 publications with CD163 and Bone
 Liver Antibodies  >110 publications with CD163 and Liver
 Lung Antibodies  >79 publications with CD163 and Lung
 Brain Antibodies  >73 publications with CD163 and Brain
 Connective Tissue Antibodies  >48 publications with CD163 and Connective Tissue
 Kidney Antibodies  >47 publications with CD163 and Kidney
 Heart Antibodies  >46 publications with CD163 and Heart
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