CAA64685.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,502 Da
NCBI Official Full Name
cofilin
NCBI Official Synonym Full Names
cofilin 1 (non-muscle)
NCBI Protein Information
cofilin-1; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15; p18
UniProt Protein Name
Cofilin-1
UniProt Synonym Protein Names
18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform
UniProt Synonym Gene Names
UniProt Entry Name
COF1_HUMAN
NCBI Summary for CFL1
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
UniProt Comments for CFL1
Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.
Protein type: Cytoskeletal; Nuclear receptor co-regulator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; nuclear matrix; membrane; cytoplasm; intercellular junction; nucleus; vesicle
Molecular Function: protein binding; actin binding
Biological Process: platelet activation; axon guidance; actin filament depolymerization; positive regulation of actin filament depolymerization; response to virus; cytoskeleton organization and biogenesis; negative regulation of cell size; response to amino acid stimulus; protein amino acid phosphorylation; Rho protein signal transduction; neural fold formation; platelet degranulation; cytokinesis after mitosis; protein import into nucleus; establishment of cell polarity; ephrin receptor signaling pathway; innate immune response; regulation of cell morphogenesis; blood coagulation; actin cytoskeleton organization and biogenesis; neural crest cell migration; negative regulation of apoptosis
Research Articles on CFL1
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Products associated with CFL1 elisa kit
Pathways associated with CFL1 elisa kit
Diseases associated with CFL1 elisa kit
Organs/Tissues associated with CFL1 elisa kit
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