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CTLA 4 elisa kit :: Rat CTLA4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2502949
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
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 Product Name   


★Popular Item★
 Also Known As   

Rat CTLA4 (Cytotoxic T-Lymphocyte Associated Antigen 4) ELISA Kit

 Product Gene Name   

CTLA 4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2502949 COA    COA PDF
 OMIM    109100
 3D Structure    ModBase 3D Structure for P16410
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 Species Reactivity    Rat
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 Specificity    This kit recognizes natural and recombinant Rat CTLA4. No significant cross-reactivity or interference between Rat CTLA4 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL ; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CTLA 4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CTLA 4 purchase    MBS2502949 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CTLA4 (CTLA 4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing CTLA 4, with an estimated sensitivity of Min: 0.094ng/mL ; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2502949 kit is based on CTLA 4 antibody-CTLA 4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CTLA 4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CTLA 4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CTLA 4 elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Rat CTLA4 concentrations in serum, plasma and other biological fluids.

Principle of the Assay||This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CTLA4. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CTLA4 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CTLA4, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CTLA4. You can calculate the concentration of CTLA4 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CTLA 4 elisa kit    CTLA 4 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2502949. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CTLA 4. It may not necessarily be applicable to this product.
 NCBI GI #    21361212
 NCBI GeneID    1493
 NCBI Accession #    NP_005205.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005214.4 [Other Products]
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 UniProt Primary Accession #    P16410 [Other Products]
 UniProt Secondary Accession #    O95653; Q0PP65; Q52MC1; Q53TD5; Q5S005; Q8WXJ1; Q96P43; Q9UKN9; A0N1S0; E9PDH0 [Other Products]
 UniProt Related Accession #    P16410 [Other Products]
 Molecular Weight    19,145 Da
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 NCBI Official Full Name    cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM
 NCBI Official Synonym Full Names    cytotoxic T-lymphocyte-associated protein 4
 NCBI Official Symbol    CTLA4 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte-associated serine esterase-4; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
 UniProt Protein Name    Cytotoxic T-lymphocyte protein 4
 UniProt Synonym Protein Names   
Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen: CD152
 UniProt Gene Name    CTLA4 [Similar Products]
 UniProt Synonym Gene Names    CD152; CTLA-4 [Similar Products]
 UniProt Entry Name    CTLA4_HUMAN
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 NCBI Summary for CTLA 4    This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CTLA 4    CTLA-4: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: Golgi apparatus; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; clathrin-coated endocytic vesicle; external side of plasma membrane

Molecular Function: protein binding

Biological Process: B cell receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of regulatory T cell differentiation; positive regulation of apoptosis; negative regulation of immune response; T cell costimulation; immune response; negative regulation of B cell proliferation; response to DNA damage stimulus

Disease: Autoimmune Lymphoproliferative Syndrome, Type V; Celiac Disease, Susceptibility To, 3; Diabetes Mellitus, Insulin-dependent, 12; Hashimoto Thyroiditis; Systemic Lupus Erythematosus
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 Research Articles on CTLA 4    1. -1722T/C and CT60A/G polymorphisms in CTLA-4 are associated with systemic lupus erythematosus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTLA 4 elisa kitPathways associated with CTLA 4 elisa kit
 Reference Product  PubMed Publications
 CD80 elisa kit  >1017 publications with CTLA 4 and CD80
 CD86 elisa kit  >655 publications with CTLA 4 and CD86
 FOXP3 elisa kit  >619 publications with CTLA 4 and FOXP3
 LCK elisa kit  >18 publications with CTLA 4 and LCK
 PTPN11 elisa kit  >13 publications with CTLA 4 and PTPN11
 CD276 elisa kit  >10 publications with CTLA 4 and CD276
 FYN elisa kit  >7 publications with CTLA 4 and FYN
 LYN elisa kit  >5 publications with CTLA 4 and LYN
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
Diseases associated with CTLA 4 elisa kitOrgans/Tissues associated with CTLA 4 elisa kit
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1633 publications with CTLA 4 and Immune System Diseases
 Melanoma Antibodies  >538 publications with CTLA 4 and Melanoma
 Inflammation Antibodies  >378 publications with CTLA 4 and Inflammation
 Necrosis Antibodies  >373 publications with CTLA 4 and Necrosis
 Arthritis, Rheumatoid Antibodies  >228 publications with CTLA 4 and Arthritis, Rheumatoid
 Carcinoma Antibodies  >199 publications with CTLA 4 and Carcinoma
 Graves Disease Antibodies  >179 publications with CTLA 4 and Graves Disease
 Liver Diseases Antibodies  >157 publications with CTLA 4 and Liver Diseases
 Neoplasms, Experimental Antibodies  >157 publications with CTLA 4 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >92 publications with CTLA 4 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3179 publications with CTLA 4 and Blood
 Lymph Node Antibodies  >247 publications with CTLA 4 and Lymph Node
 Lung Antibodies  >213 publications with CTLA 4 and Lung
 Kidney Antibodies  >206 publications with CTLA 4 and Kidney
 Prostate Antibodies  >87 publications with CTLA 4 and Prostate
 Mammary Gland Antibodies  >1 publications with CTLA 4 and Mammary Gland
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