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PNPLA8 elisa kit :: Rat Calcium-independent phospholipase A2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7209028 PNPLA8 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calcium-independent phospholipase A2 (PNPLA8), ELISA Kit

 Also Known As   

Rat Calcium-independent phospholipase A2 ELISA Kit

 Product Gene Name   

PNPLA8 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    612953
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 Species Reactivity    Rat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PNPLA8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PNPLA8 purchase    MBS7209028 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calcium-independent phospholipase A2 (PNPLA8) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PNPLA8. The ELISA analytical biochemical technique of the MBS7209028 kit is based on PNPLA8 antibody-PNPLA8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PNPLA8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PNPLA8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PNPLA8. It may not necessarily be applicable to this product.
 NCBI GI #    3142700
 NCBI GeneID    8398
 NCBI Accession #    AAC97486.1 [Other Products]
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 UniProt Secondary Accession #    O75645; Q8N452; Q9UG29; Q9UIT0; Q9Y671; A8K597; B0QYE8 [Other Products]
 UniProt Related Accession #    O60733 [Other Products]
 Molecular Weight    46,484 Da
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 NCBI Official Full Name    calcium-independent phospholipase A2
 NCBI Official Synonym Full Names    phospholipase A2, group VI (cytosolic, calcium-independent)
 NCBI Official Symbol    PLA2G6 [Similar Products]
 NCBI Official Synonym Symbols   
GVI; PLA2; INAD1; NBIA2; iPLA2; NBIA2A; NBIA2B; PARK14; PNPLA9; CaI-PLA2; IPLA2-VIA; iPLA2beta
[Similar Products]
 NCBI Protein Information    85/88 kDa calcium-independent phospholipase A2; GVI PLA2; iPLA2-beta; group VI phospholipase A2; 85 kDa calcium-independent phospholipase A2; patatin-like phospholipase domain containing 9; cytosolic, calcium-independent phospholipase A2; neurodegeneration with brain iron accumulation 2; patatin-like phospholipase domain-containing protein 9; intracellular membrane-associated calcium-independent phospholipase A2 beta
 UniProt Protein Name    85/88 kDa calcium-independent phospholipase A2
 UniProt Synonym Protein Names   
Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; Patatin-like phospholipase domain-containing protein 9; PNPLA9
 Protein Family    Calcium-independent phospholipase
 UniProt Gene Name    PLA2G6 [Similar Products]
 UniProt Synonym Gene Names    PLPLA9; CaI-PLA2; GVI PLA2; iPLA2-beta; PNPLA9 [Similar Products]
 UniProt Entry Name    PLPL9_HUMAN
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 NCBI Summary for PNPLA8    The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
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 UniProt Comments for PNPLA8    PLA2G6: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods. Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2B (NBIA2B). A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment. Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2A (NBIA2A); also known as Seitelberger disease. NBIA2A is a neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years. Defects in PLA2G6 are the cause of Parkinson disease type 14 (PARK14). An adult-onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.4; Phospholipase; Lipid Metabolism - linoleic acid; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: mitochondrion; membrane; cytoplasm; microtubule organizing center; cytosol

Molecular Function: phospholipase A2 activity; calmodulin binding; ATP-dependent protein binding; calcium-independent phospholipase A2 activity

Biological Process: urinary bladder smooth muscle contraction; cardiolipin biosynthetic process; maternal process involved in pregnancy; glycerophospholipid biosynthetic process; negative regulation of synaptic transmission, glutamatergic; positive regulation of vasodilation; chemotaxis; memory; elevation of cytosolic calcium ion concentration; phospholipid metabolic process; innate immune response; positive regulation of protein amino acid phosphorylation; lipid catabolic process; positive regulation of exocytosis

Disease: Parkinson Disease 14, Autosomal Recessive; Neurodegeneration With Brain Iron Accumulation 2b; Neurodegeneration With Brain Iron Accumulation 2a
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 Research Articles on PNPLA8    1. clinical findings may be helpful in distinguishing PLA2G6-related neurodegeneration from the other major cause of NBIA, recessive PANK2 mutations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PNPLA8 elisa kitPathways associated with PNPLA8 elisa kit
 Reference Product  PubMed Publications
 PLA2G4A elisa kit  >104 publications with PNPLA8 and PLA2G4A
 PTGS2 elisa kit  >13 publications with PNPLA8 and PTGS2
 PTGS1 elisa kit  >11 publications with PNPLA8 and PTGS1
 ALOX5 elisa kit  >2 publications with PNPLA8 and ALOX5
 PLA2G7 elisa kit  >1 publications with PNPLA8 and PLA2G7
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of CL Pathway antibodies  Acyl Chain Remodeling Of CL Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
Diseases associated with PNPLA8 elisa kitOrgans/Tissues associated with PNPLA8 elisa kit
 Disease Name  Pubmed Publications
 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A Antibodies  >41 publications with PNPLA8 and NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A
 Inflammation Antibodies  >28 publications with PNPLA8 and Inflammation
 Atrophy Antibodies  >25 publications with PNPLA8 and Atrophy
 Cardiovascular Diseases Antibodies  >18 publications with PNPLA8 and Cardiovascular Diseases
 Ischemia Antibodies  >11 publications with PNPLA8 and Ischemia
 Atherosclerosis Antibodies  >10 publications with PNPLA8 and Atherosclerosis
 Fatty Liver Antibodies  >7 publications with PNPLA8 and Fatty Liver
 Necrosis Antibodies  >6 publications with PNPLA8 and Necrosis
 Neoplasms, Experimental Antibodies  >6 publications with PNPLA8 and Neoplasms, Experimental
 Nerve Degeneration Antibodies  >6 publications with PNPLA8 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >102 publications with PNPLA8 and Brain
 Blood Antibodies  >45 publications with PNPLA8 and Blood
 Pancreas Antibodies  >21 publications with PNPLA8 and Pancreas
 Nerve Antibodies  >15 publications with PNPLA8 and Nerve
 Kidney Antibodies  >14 publications with PNPLA8 and Kidney
 Eye Antibodies  >14 publications with PNPLA8 and Eye
 Lung Antibodies  >11 publications with PNPLA8 and Lung
 Skin Antibodies  >10 publications with PNPLA8 and Skin
 Liver Antibodies  >9 publications with PNPLA8 and Liver
 Ovary Antibodies  >6 publications with PNPLA8 and Ovary
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