NP_001267.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,625 Da
NCBI Official Full Name
chitinase-3-like protein 1
NCBI Official Synonym Full Names
chitinase 3-like 1 (cartilage glycoprotein-39)
NCBI Official Synonym Symbols
GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39 [Similar Products]
NCBI Protein Information
chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39
UniProt Protein Name
Chitinase-3-like protein 1
UniProt Synonym Protein Names
39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40
UniProt Synonym Gene Names
UniProt Entry Name
CH3L1_HUMAN
NCBI Summary for YKL40
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
UniProt Comments for YKL40
CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family.
Protein type: Secreted; Secreted, signal peptide; Cell adhesion
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: extracellular space; proteinaceous extracellular matrix; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm
Molecular Function: extracellular matrix structural constituent; chitin binding; chitinase activity; carbohydrate binding
Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; apoptosis; response to mechanical stimulus; cartilage development; carbohydrate metabolic process; activation of NF-kappaB-inducing kinase; immune response; chitin catabolic process; inflammatory response; lung development
Disease: Schizophrenia; Asthma-related Traits, Susceptibility To, 7
Research Articles on YKL40
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Products associated with YKL40 elisa kit
Diseases associated with YKL40 elisa kit
Organs/Tissues associated with YKL40 elisa kit
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