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Catn-C elisa kit :: Rat Cathepsin C ELISA Kit

Scan QR to view Datasheet Catalog #    MBS738346
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin C (Catn-C), ELISA Kit

★Popular Item★
 Also Known As   

Rat Cathepsin C ELISA Kit

 Product Gene Name   

Catn-C elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    602365
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of CTSC. No significant cross-reactivity or interference between CTSC and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between CTSC and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Sandwich
 Detection Range    1.0-25ng/mL
 Sensitivity    0.1ng/ml
 Intended Uses    This CTSC ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Rat CTSC. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of Catn-C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Catn-C purchase    MBS738346 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cathepsin C (Catn-C) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.0-25ng/mL in biological research samples containing Catn-C, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS738346 kit is based on Catn-C antibody-Catn-C antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Catn-C antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Catn-C. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for Catn-C elisa kit

   Principle of the assay: CTSC ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-CTSC antibody and an CTSC-HRP conjugate. The assay sample and buffer are incubated together with CTSC-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the CTSC concentration since CTSC from samples and CTSC-HRP conjugate compete for the anti-CTSC antibody binding site. Since the number of sites is limited, as more sites are occupied by CTSC from the sample, fewer sites are left to bind CTSC-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The CTSC concentration in each sample is interpolated from this standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of Catn-C elisa kit    Catn-C elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS738346. Click to request current manual
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NCBI/Uniprot data below describe general gene information for Catn-C. It may not necessarily be applicable to this product.
 NCBI GI #    33327024
 NCBI GeneID    1075
 NCBI Accession #    AAQ08887.1 [Other Products]
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 UniProt Secondary Accession #    Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; A8K7V2; B5MDD5 [Other Products]
 UniProt Related Accession #    P53634 [Other Products]
 Molecular Weight    15,700 Da
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 NCBI Official Full Name    cathepsin C
 NCBI Official Synonym Full Names    cathepsin C
 NCBI Official Symbol    CTSC [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    dipeptidyl peptidase 1; cathepsin J; dipeptidyl peptidase I; dipeptidyl transferase; dipeptidyl-peptidase I
 UniProt Protein Name    Dipeptidyl peptidase 1
 UniProt Synonym Protein Names   
Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferaseCleaved into the following 3 chains:Dipeptidyl peptidase 1 exclusion domain chainAlternative name(s):Dipeptidyl peptidase I exclusion domain chain
 Protein Family    Cathepsin
 UniProt Gene Name    CTSC [Similar Products]
 UniProt Synonym Gene Names    CPPI; DPP-I; DPPI [Similar Products]
 UniProt Entry Name    CATC_HUMAN
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 NCBI Summary for Catn-C    The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Catn-C    CTSC: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. Defects in CTSC are a cause of Papillon-Lefevre syndrome (PLS); also known as keratosis palmoplantaris with periodontopathia. PLS is an autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. Defects in CTSC are a cause of Haim-Munk syndrome (HMS); also known as keratosis palmoplantaris with periodontopathia and onychogryposis or Cochin Jewish disorder. HMS is an autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. Defects in CTSC are a cause of aggressive periodontititis type 1 (AP1); also known as juvenile periodontitis (JPD) and prepubertal periodontitis (PPP). AP1 is characterized by severe and protracted gingival infections, leading to tooth loss. AP1 inheritance is autosomal dominant. Belongs to the peptidase C1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Protease; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 11q14.2

Cellular Component: Golgi apparatus; extracellular space; membrane; endoplasmic reticulum; lysosome

Molecular Function: identical protein binding; protein binding; protein self-association; chaperone binding; serine-type endopeptidase activity; apoptotic protease activator activity; chloride ion binding; cysteine-type peptidase activity; phosphatase binding

Biological Process: response to organic substance; apoptosis; immune response; proteolysis; aging; T cell mediated cytotoxicity

Disease: Periodontitis, Aggressive, 1; Papillon-lefevre Syndrome; Haim-munk Syndrome
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 Research Articles on Catn-C    1. CTSC mutations in 5 Iranian families with Papillon-Lefevre syndrome (PLS)analyzed; modeled the protein for mutations found in 2 of them; presence of this mutation provides evidence for founder CTSC mutations in PLS; this P35delL mutation leads to loss of a leucine residue; results indicate the phenotypes in these 2 patients likely due to CTSC mutations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Catn-C elisa kitDiseases associated with Catn-C elisa kit
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Disease Name  Pubmed Publications
 Papillon-Lefevre Disease Antibodies  >43 publications with Catn-C and Papillon-Lefevre Disease
 Periodontal Diseases Antibodies  >18 publications with Catn-C and Periodontal Diseases
 Aggressive Periodontitis Antibodies  >14 publications with Catn-C and Aggressive Periodontitis
 Disease Models, Animal Antibodies  >8 publications with Catn-C and Disease Models, Animal
 Inflammation Antibodies  >7 publications with Catn-C and Inflammation
 Necrosis Antibodies  >4 publications with Catn-C and Necrosis
 Liver Diseases Antibodies  >4 publications with Catn-C and Liver Diseases
 Disease Progression Antibodies  >3 publications with Catn-C and Disease Progression
 Neoplasms, Experimental Antibodies  >2 publications with Catn-C and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >2 publications with Catn-C and Breast Neoplasms
Organs/Tissues associated with Catn-C elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with Catn-C and Blood
 Skin Antibodies  >14 publications with Catn-C and Skin
 Bone Antibodies  >8 publications with Catn-C and Bone
 Brain Antibodies  >7 publications with Catn-C and Brain
 Liver Antibodies  >5 publications with Catn-C and Liver
 Bone Marrow Antibodies  >4 publications with Catn-C and Bone Marrow
 Heart Antibodies  >4 publications with Catn-C and Heart
 Mouth Antibodies  >4 publications with Catn-C and Mouth
 Lung Antibodies  >4 publications with Catn-C and Lung
 Eye Antibodies  >3 publications with Catn-C and Eye
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