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COL-IV Ab elisa kit :: Rat Collagen Type IV Antibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS019030 COL-IV Ab elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Collagen Type IV Antibody (COL-IV Ab), ELISA Kit

 Also Known As   

Rat Collagen Type IV Antibody ELISA Kit

 Product Gene Name   

COL-IV Ab elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    300914
 3D Structure    ModBase 3D Structure for Q14031
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 Species Reactivity    Rat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COL-IV Ab elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COL-IV Ab purchase    MBS019030 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Type IV Antibody (COL-IV Ab) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COL-IV Ab. The ELISA analytical biochemical technique of the MBS019030 kit is based on COL-IV Ab antibody-COL-IV Ab antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL-IV Ab antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL-IV Ab. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for COL-IV Ab. It may not necessarily be applicable to this product.
 NCBI GI #    567757604
 NCBI GeneID    1288
 NCBI Accession #    NP_001274689.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001287760.1 [Other Products]
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 UniProt Primary Accession #    Q14031 [Other Products]
 UniProt Secondary Accession #    Q12823; Q14053; Q5JYH6; Q5JYH8; Q9NQM5; Q9NTX3; Q9UJ76; Q9UMG6; Q9Y4L4 [Other Products]
 UniProt Related Accession #    Q14031 [Other Products]
 Molecular Weight    163,807 Da
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 NCBI Official Full Name    collagen alpha-6(IV) chain isoform 5
 NCBI Official Synonym Full Names    collagen, type IV, alpha 6
 NCBI Official Symbol    COL4A6 [Similar Products]
 NCBI Official Synonym Symbols   
DFNX6; DELXq22.3; CXDELq22.3
[Similar Products]
 NCBI Protein Information    collagen alpha-6(IV) chain; collagen alpha-6(IV) chain; collagen IV, alpha-6 polypeptide; dJ889N15.4 (Collagen Alpha 6(IV)); collagen of basement membrane, alpha-6
 UniProt Protein Name    Collagen alpha-6(IV) chain
 UniProt Gene Name    COL4A6 [Similar Products]
 UniProt Entry Name    CO4A6_HUMAN
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 NCBI Summary for COL-IV Ab    This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
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 UniProt Comments for COL-IV Ab    COL4A6: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS). Belongs to the type IV collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Extracellular matrix; Secreted

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: endoplasmic reticulum lumen; collagen type IV; extracellular region

Molecular Function: extracellular matrix structural constituent

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; cell adhesion

Disease: Deafness, X-linked 6
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 Research Articles on COL-IV Ab    1. We showed that TPM2, CLU, and COL4A6 mRNA levels are downregulated in prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with COL-IV Ab elisa kitDiseases associated with COL-IV Ab elisa kit
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >36 publications with COL-IV Ab and Congenital Abnormalities
 Nephritis Antibodies  >35 publications with COL-IV Ab and Nephritis
 Neoplasms Antibodies  >31 publications with COL-IV Ab and Neoplasms
 Leiomyomatosis, esophageal and vulval, with nephropathy Antibodies  >3 publications with COL-IV Ab and Leiomyomatosis, esophageal and vulval, with nephropathy
 Skin Neoplasms Antibodies  >2 publications with COL-IV Ab and Skin Neoplasms
 Hypertrophy Antibodies  >2 publications with COL-IV Ab and Hypertrophy
 Proteinuria Antibodies  >2 publications with COL-IV Ab and Proteinuria
 Disease Models, Animal Antibodies  >2 publications with COL-IV Ab and Disease Models, Animal
 Hemorrhage Antibodies  >2 publications with COL-IV Ab and Hemorrhage
 Hypertension Antibodies  >1 publications with COL-IV Ab and Hypertension
Organs/Tissues associated with COL-IV Ab elisa kit
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >19 publications with COL-IV Ab and Muscle
 Esophagus Antibodies  >14 publications with COL-IV Ab and Esophagus
 Skin Antibodies  >11 publications with COL-IV Ab and Skin
 Eye Antibodies  >4 publications with COL-IV Ab and Eye
 Stomach Antibodies  >2 publications with COL-IV Ab and Stomach
 Uterus Antibodies  >2 publications with COL-IV Ab and Uterus
 Embryonic Tissue Antibodies  >2 publications with COL-IV Ab and Embryonic Tissue
 Placenta Antibodies  >1 publications with COL-IV Ab and Placenta
 Testis Antibodies  >1 publications with COL-IV Ab and Testis
 Lung Antibodies  >1 publications with COL-IV Ab and Lung
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