NP_434690.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
162,093 Da
NCBI Official Full Name
copper-transporting ATPase 1
NCBI Official Synonym Full Names
ATPase copper transporting alpha
NCBI Official Synonym Symbols
NCBI Protein Information
copper-transporting ATPase 1
UniProt Protein Name
Copper-transporting ATPase 1
UniProt Synonym Protein Names
Copper pump 1; Menkes disease-associated protein homolog
UniProt Synonym Gene Names
UniProt Entry Name
ATP7A_RAT
NCBI Summary for Atp7a
This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. In human, mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq, Nov 2009]
UniProt Comments for Atp7a
ATP7A: a multi-pass membrane protein and cation transporting ATPase. A copper-transporter that may supply copper to copper-requiring proteins within the secretory pathway when localized in the trans-Golgi network. Cycles between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalizes to the plasma membrane in response to elevated extracellular copper levels where it functions in the efflux of copper from cells. Defects in ATP7A are the cause of Menkes syndrome (MD) and occipital horn syndrome (OHS). Six alternatively spliced isoforms have been described. The longest isoform has 6 transmembrane regions. Isoform 3, lacking all 6 transmembrane regions and 5 heavy-metal-associated (HMA) domains, is probably cytosolic. Isoform 6 lacks all transmembrane regions and 5 heavy-metal-associated (HMA) domains, but has a putative nuclear localization signal attached at the N-terminus.
Protein type: Vesicle; Chaperone; EC 3.6.3.54; Apoptosis; Membrane protein, multi-pass; Transporter, ion channel; Transporter; Hydrolase; Membrane protein, integral; Cell development/differentiation
Cellular Component: basolateral plasma membrane; brush border membrane; cell soma; cytoplasmic vesicle; endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; late endosome; membrane; neuron projection; perinuclear region of cytoplasm; plasma membrane; secretory granule; trans-Golgi network; trans-Golgi network transport vesicle
Molecular Function: ATP binding; copper ion binding; copper ion transmembrane transporter activity; copper-dependent protein binding; copper-exporting ATPase activity; metal ion binding; superoxide dismutase copper chaperone activity
Biological Process: alveolus development; ATP metabolic process; blood vessel development; blood vessel remodeling; cartilage development; catecholamine metabolic process; cellular copper ion homeostasis; central nervous system neuron development; cerebellar Purkinje cell differentiation; collagen fibril organization; copper ion export; copper ion import; copper ion transport; dendrite morphogenesis; detoxification of copper ion; dopamine metabolic process; elastic fiber assembly; elastin biosynthetic process; epinephrine metabolic process; extracellular matrix organization and biogenesis; hair follicle morphogenesis; hindlimb morphogenesis; in utero embryonic development; lactation; locomotory behavior; metal ion transport; mitochondrion organization and biogenesis; negative regulation of metalloenzyme activity; negative regulation of neuron apoptosis; neurite morphogenesis; norepinephrine biosynthetic process; norepinephrine metabolic process; peptidyl-lysine modification; pigmentation; plasma membrane copper ion transport; positive regulation of catalytic activity; positive regulation of metalloenzyme activity; positive regulation of oxidoreductase activity; pyramidal neuron development; regulation of gene expression; regulation of oxidative phosphorylation; release of cytochrome c from mitochondria; removal of superoxide radicals; response to copper ion; response to iron(III) ion; response to zinc ion; serotonin metabolic process; skin development; T-helper cell differentiation; tryptophan metabolic process; tyrosine metabolic process
Research Articles on Atp7a
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Products associated with Atp7a elisa kit
Pathways associated with Atp7a elisa kit
Diseases associated with Atp7a elisa kit
Organs/Tissues associated with Atp7a elisa kit
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