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Cdkn2a elisa kit :: Rat Cyclin-dependent kinase inhibitor 2A, isoform 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS289721 Cdkn2a elisa kit
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cyclin-dependent kinase inhibitor 2A, isoform 1 (Cdkn2a), ELISA Kit

★Popular Item★
 Also Known As   

Rat Cyclin-dependent kinase inhibitor 2A, isoform 1 ELISA Kit

 Product Synonym Names    Cyclin-dependent kinase inhibitor 2A, isoform 2; p19ARF; Cdkn2a
 Product Gene Name   

Cdkn2a elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for Q8QZZ9
 Species Reactivity    Rat
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 Assay Type    Sandwich
 Detection Range    0.156-10 ng/ml
 Sensitivity    0.09 ng/mL
 Intra-Assay CV    <=6.8%
 Inter-Assay CV    <=10.1%
 Recovery    110%
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of Cdkn2a elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Cdkn2a purchase    MBS289721 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cyclin-dependent kinase inhibitor 2A, isoform 1 (Cdkn2a) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10 ng/ml in biological research samples containing Cdkn2a, with an estimated sensitivity of 0.09 ng/mL. The ELISA analytical biochemical technique of the MBS289721 kit is based on Cdkn2a antibody-Cdkn2a antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Cdkn2a antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Cdkn2a. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for Cdkn2a. It may not necessarily be applicable to this product.
 NCBI GI #    77416387
 NCBI GeneID    25163
 NCBI Accession #    Q8QZZ9.1 [Other Products]
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 UniProt Primary Accession #    Q8QZZ9 [Other Products]
 UniProt Related Accession #    Q9R0Z3; Q8QZZ9 [Other Products]
 Molecular Weight    17,366 Da
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 NCBI Official Full Name    Tumor suppressor ARF
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 2A
 NCBI Official Symbol    Cdkn2a [Similar Products]
 NCBI Official Synonym Symbols   
Arf; p16; MTS1; INK4A; p19ARF; p16Cdkn2a
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 2A
 UniProt Protein Name    Tumor suppressor ARF
 UniProt Synonym Protein Names   
Alternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p19ARF
 Protein Family    Cyclin-dependent kinase inhibitor
 UniProt Gene Name    Cdkn2a [Similar Products]
 UniProt Synonym Gene Names    ARF [Similar Products]
 UniProt Entry Name    ARF_RAT
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 NCBI Summary for Cdkn2a    tumor suppressor that inhibits CDK4; inactivation or loss is associated with cellular transformation; may be involved in CNS degeneration following injury [RGD, Feb 2006]
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 UniProt Comments for Cdkn2a    p16-INK4A: a cell-cycle regulatory protein that interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6, and entry into the S phase of the cell cycle. The p16INK4A and p14ARF proteins are encoded by CDKN2A, a known tumour suppressor gene in multiple cancers. CDKN2A is inactivated in 72% of cases of lung squamous cell carcinoma: 21% by epigenetic silencing by methylation, 18% inactivating mutation, 4% by exon 1b skipping, and 29% by homozygous deletion. Defects in CDKN2A are the cause of familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, Li-Fraumeni syndrome, and the melanoma-astrocytoma syndrome. The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. Four alternatively spliced p16 isoforms have been reported. Two alternatively spliced isoforms of ARF have been reported.

Protein type: Cell cycle regulation; Tumor suppressor; Nucleolus

Cellular Component: cytoplasm; granular component; mitochondrion; nuclear body; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: cyclin-dependent protein kinase inhibitor activity; DNA binding; NF-kappaB binding; p53 binding; protein kinase binding; protein N-terminus binding; transcription factor activity; transcription factor binding; ubiquitin-protein ligase inhibitor activity

Biological Process: aging; apoptosis; apoptotic mitochondrial changes; caspase activation; cell aging; cell cycle arrest; cerebellum development; epidermis development; G1/S transition of mitotic cell cycle; glucose homeostasis; inhibition of NF-kappaB transcription factor; mitochondrial depolarization; mitochondrion degradation; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of cyclin-dependent protein kinase activity; negative regulation of immature T cell proliferation in the thymus; negative regulation of mammary gland epithelial cell proliferation; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; negative regulation of ubiquitin-protein ligase activity; positive regulation of apoptosis; positive regulation of apoptosis involved in mammary gland involution; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of protein sumoylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein destabilization; protein polyubiquitination; protein stabilization; Ras protein signal transduction; regulation of cyclin-dependent protein kinase activity; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of nucleocytoplasmic transport; regulation of protein export from nucleus; regulation of protein stability; regulation of transcription, DNA-dependent; response to drug; response to organic cyclic substance; response to organic nitrogen; response to organic substance; rRNA processing; rRNA transcription; somatic stem cell division; somatic stem cell maintenance; transcription, DNA-dependent
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 Research Articles on Cdkn2a    1. These findings indicate that p16(INK4a) plays a significant role in the inhibition of DNA synthesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Cdkn2a elisa kit
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 G1 To S Cell Cycle Control Pathway antibodies  G1 To S Cell Cycle Control Pathway Diagram
 Glioma Pathway antibodies  Glioma Pathway Diagram
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