AAA51980.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,230 Da
NCBI Official Full Name
CFTR, partial
NCBI Official Synonym Full Names
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NCBI Official Synonym Symbols
CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1 [Similar Products]
NCBI Protein Information
cystic fibrosis transmembrane conductance regulator; cAMP-dependent chloride channel; channel conductance-controlling ATPase
UniProt Protein Name
Cystic fibrosis transmembrane conductance regulator
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49); cAMP-dependent chloride channel
UniProt Synonym Gene Names
UniProt Entry Name
CFTR_HUMAN
NCBI Summary for CFTR
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CFTR
CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice
Protein type: EC 3.6.3.49; Transporter, ABC family; Hydrolase; Channel, chloride; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component: recycling endosome; protein complex; cell surface; microvillus; cytoplasmic vesicle membrane; basolateral plasma membrane; early endosome membrane; apical plasma membrane; cytoplasm; early endosome; plasma membrane
Molecular Function: bicarbonate transmembrane transporter activity; protein binding; chloride channel activity; enzyme binding; chloride channel inhibitor activity; chloride transmembrane transporter activity; ATP-binding and phosphorylation-dependent chloride channel activity; channel-conductance-controlling ATPase activity; ATP binding; PDZ domain binding
Biological Process: intracellular pH elevation; response to drug; response to peptide hormone stimulus; cholesterol transport; iodide transport; water transport; transepithelial chloride transport; membrane hyperpolarization; respiratory gaseous exchange; positive regulation of vasodilation; cholesterol biosynthetic process; vasodilation; cellular response to hormone stimulus; response to estrogen stimulus; transport; bicarbonate transport; response to cytokine stimulus; transmembrane transport; sperm capacitation; lung development
Disease: Vas Deferens, Congenital Bilateral Aplasia Of; Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary
Research Articles on CFTR
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Products associated with CFTR elisa kit
Pathways associated with CFTR elisa kit
Diseases associated with CFTR elisa kit
Organs/Tissues associated with CFTR elisa kit
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