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DRD2 elisa kit :: Rat DRD2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2505684
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DRD2, ELISA Kit

★Popular Item★
 Also Known As   

Rat DRD2 (Dopamine Receptor D2) ELISA Kit

 Product Gene Name   

DRD2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    103780
 3D Structure    ModBase 3D Structure for P14416
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Rat DRD2. No significant cross-reactivity or interference between Rat DRD2 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Rat DRD2 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    1.563-100mIU/mL
 Sensitivity    Min: 0.938mIU/mL; Max: 100mIU/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DRD2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DRD2 purchase    MBS2505684 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the DRD2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.563-100mIU/mL in biological research samples containing DRD2, with an estimated sensitivity of Min: 0.938mIU/mL; Max: 100mIU/mL. The ELISA analytical biochemical technique of the MBS2505684 kit is based on DRD2 antibody-DRD2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DRD2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DRD2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for DRD2 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of DRD2 in Rat serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat DRD2. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Rat DRD2 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat DRD2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Rat DRD2. You can calculate the concentration of Rat DRD2 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of DRD2 elisa kit    DRD2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2505684. Click to request current manual
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NCBI/Uniprot data below describe general gene information for DRD2. It may not necessarily be applicable to this product.
 NCBI GI #    4503385
 NCBI GeneID    1813
 NCBI Accession #    NP_000786.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000795.3 [Other Products]
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 UniProt Primary Accession #    P14416 [Other Products]
 UniProt Secondary Accession #    Q9NZR3; Q9UPA9 [Other Products]
 UniProt Related Accession #    P14416 [Other Products]
 Molecular Weight    50,847 Da
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 NCBI Official Full Name    D(2) dopamine receptor isoform long
 NCBI Official Synonym Full Names    dopamine receptor D2
 NCBI Official Symbol    DRD2 [Similar Products]
 NCBI Official Synonym Symbols   
D2R; D2DR
[Similar Products]
 NCBI Protein Information    D(2) dopamine receptor; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor
 UniProt Protein Name    D(2) dopamine receptor
 UniProt Synonym Protein Names   
Dopamine D2 receptor
 Protein Family    D(2) dopamine receptor
 UniProt Gene Name    DRD2 [Similar Products]
 UniProt Entry Name    DRD2_HUMAN
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 NCBI Summary for DRD2    This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DRD2    DRD2: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: synaptic vesicle membrane; endocytic vesicle; integral to plasma membrane; axon; dendrite; postsynaptic density; plasma membrane; dendritic spine; acrosome; perikaryon; nerve terminal; lateral plasma membrane

Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; ionotropic glutamate receptor binding; protein binding; potassium channel regulator activity; protein homodimerization activity; protein heterodimerization activity; dopamine binding; drug binding

Biological Process: response to nicotine; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); prepulse inhibition; positive regulation of dopamine uptake; response to toxin; positive regulation of receptor internalization; thermoregulation; positive regulation of multicellular organism growth; regulation of phosphoprotein phosphatase activity; dopamine metabolic process; adult walking behavior; dopamine receptor, adenylate cyclase inhibiting pathway; negative regulation of insulin secretion; protein localization; negative regulation of blood pressure; phosphatidylinositol metabolic process; response to drug; response to light stimulus; response to inactivity; positive regulation of neuroblast proliferation; cerebral cortex GABAergic interneuron migration; negative regulation of synaptic transmission, glutamatergic; regulation of sodium ion transport; arachidonic acid secretion; regulation of synaptic transmission, GABAergic; positive regulation of growth hormone secretion; G-protein coupled receptor internalization; reduction of cytosolic calcium ion concentration; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; peristalsis; branching morphogenesis of a nerve; negative regulation of circadian sleep/wake cycle, sleep; response to morphine; locomotory behavior; behavioral response to ethanol; orbitofrontal cortex development; negative regulation of cell proliferation; synaptogenesis; behavioral response to cocaine; visual learning; adenohypophysis development; nerve-nerve synaptic transmission; feeding behavior; circadian regulation of gene expression; response to axon injury; negative regulation of dopamine secretion; negative regulation of cell migration; response to iron ion; associative learning; grooming behavior; positive regulation of cytokinesis; negative regulation of protein secretion; Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; striatum development; regulation of heart rate; regulation of cAMP metabolic process; regulation of potassium ion transport; negative regulation of adenylate cyclase activity; sensory perception of smell; response to amphetamine; regulation of dopamine uptake; auditory behavior; response to cocaine; cellular calcium ion homeostasis; regulation of systemic arterial blood pressure by neurological process; negative regulation of dopamine receptor signaling pathway; axonogenesis; pigmentation; long-term memory; positive regulation of G-protein coupled receptor protein signaling pathway; release of sequestered calcium ion into cytosol; response to hypoxia; regulation of synapse structural plasticity; dopamine receptor, phospholipase C activating pathway

Disease: Myoclonic Dystonia
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 Research Articles on DRD2    1. glycosylation on the N-terminus mediates the internalization of Dand Dreceptors within the caveolae and clathrin-coated pit microdomains of the plasma membrane
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DRD2 elisa kitPathways associated with DRD2 elisa kit
 Reference Product  PubMed Publications
 SLC6A3 elisa kit  >202 publications with DRD2 and SLC6A3
 PDYN elisa kit  >4 publications with DRD2 and PDYN
 RGS4 elisa kit  >3 publications with DRD2 and RGS4
 PENK elisa kit  >3 publications with DRD2 and PENK
 POMC elisa kit  >3 publications with DRD2 and POMC
 SSTR5 elisa kit  >2 publications with DRD2 and SSTR5
 FLNA elisa kit  >1 publications with DRD2 and FLNA
 GNAI2 elisa kit  >1 publications with DRD2 and GNAI2
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
Diseases associated with DRD2 elisa kitOrgans/Tissues associated with DRD2 elisa kit
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >709 publications with DRD2 and Mental Disorders
 Substance-Related Disorders Antibodies  >314 publications with DRD2 and Substance-Related Disorders
 Schizophrenia Antibodies  >269 publications with DRD2 and Schizophrenia
 Nervous System Diseases Antibodies  >239 publications with DRD2 and Nervous System Diseases
 Movement Disorders Antibodies  >123 publications with DRD2 and Movement Disorders
 Basal Ganglia Diseases Antibodies  >97 publications with DRD2 and Basal Ganglia Diseases
 Attention Deficit Disorder with Hyperactivity Antibodies  >67 publications with DRD2 and Attention Deficit Disorder with Hyperactivity
 Dyskinesias Antibodies  >59 publications with DRD2 and Dyskinesias
 Bipolar Disorder Antibodies  >58 publications with DRD2 and Bipolar Disorder
 Parkinson Disease Antibodies  >54 publications with DRD2 and Parkinson Disease
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >426 publications with DRD2 and Brain
 Nerve Antibodies  >56 publications with DRD2 and Nerve
 Ganglia Antibodies  >43 publications with DRD2 and Ganglia
 Pituitary Gland Antibodies  >14 publications with DRD2 and Pituitary Gland
 Lung Antibodies  >11 publications with DRD2 and Lung
 Muscle Antibodies  >6 publications with DRD2 and Muscle
 Eye Antibodies  >5 publications with DRD2 and Eye
 Pancreas Antibodies  >4 publications with DRD2 and Pancreas
 Intestine Antibodies  >2 publications with DRD2 and Intestine
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