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EDNRB elisa kit :: Rat Endothelin B receptor (EDNRB) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7249903 EDNRB elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endothelin B receptor (EDNRB), ELISA Kit

★Popular Item★
 Also Known As   

Rat Endothelin B receptor (EDNRB) ELISA Kit

 Product Gene Name   

EDNRB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    600501
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 Species Reactivity    Rat
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of EDNRB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for EDNRB purchase    MBS7249903 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Endothelin B receptor (EDNRB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EDNRB. The ELISA analytical biochemical technique of the MBS7249903 kit is based on EDNRB antibody-EDNRB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EDNRB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EDNRB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for EDNRB elisa kit    Signal Transduction
Sample Manual Insert of MBS7249903. Click to request current manual
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NCBI/Uniprot data below describe general gene information for EDNRB. It may not necessarily be applicable to this product.
 NCBI GI #    4557547
 NCBI GeneID    1910
 NCBI Accession #    NP_000106.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000115.3 [Other Products]
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 UniProt Secondary Accession #    O15343; Q59GB1; Q5W0G9; Q8NHM6; Q8NHM7; Q8NHM8; Q8NHM9; Q9UD23; Q9UQK3; A2A2Z8; A8K3T4 [Other Products]
 UniProt Related Accession #    P24530; AAB24922 [Other Products]
 Molecular Weight    59,480 Da
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 NCBI Official Full Name    endothelin B receptor isoform 1
 NCBI Official Synonym Full Names    endothelin receptor type B
 NCBI Official Symbol    EDNRB [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    endothelin B receptor; endothelin receptor non-selective type
 UniProt Protein Name    Endothelin B receptor
 UniProt Synonym Protein Names   
Endothelin receptor non-selective type
 Protein Family    Endothelin B receptor
 UniProt Gene Name    EDNRB [Similar Products]
 UniProt Synonym Gene Names    ETRB; ET-B; ET-BR [Similar Products]
 UniProt Entry Name    EDNRB_HUMAN
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 NCBI Summary for EDNRB    The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
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 UniProt Comments for EDNRB    ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: nuclear membrane; integral to plasma membrane; plasma membrane; lipid raft

Molecular Function: endothelin receptor activity; protein binding; peptide hormone binding; type 1 angiotensin receptor binding

Biological Process: epithelial fluid transport; cGMP-mediated signaling; regulation of fever; response to pain; negative regulation of cellular protein metabolic process; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; vein smooth muscle contraction; enteric nervous system development; response to organic cyclic substance; vasodilation; regulation of epithelial cell proliferation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; regulation of blood pressure; melanocyte differentiation; positive regulation of cell proliferation; regulation of pH; neural crest cell migration; aging; posterior midgut development; nervous system development; vasoconstriction; negative regulation of adenylate cyclase activity; macrophage chemotaxis; peripheral nervous system development; negative regulation of neuron maturation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis

Disease: Waardenburg Syndrome, Type 4a; Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2
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 Research Articles on EDNRB    1. There was no difference in EDNRB mRNA expression between reflux esophagitis, Barrett's esophagus, and controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with EDNRB elisa kitDiseases associated with EDNRB elisa kit
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Disease Name  Pubmed Publications
 Hirschsprung Disease Antibodies  >138 publications with EDNRB and Hirschsprung Disease
 Nervous System Diseases Antibodies  >42 publications with EDNRB and Nervous System Diseases
 Disease Models, Animal Antibodies  >33 publications with EDNRB and Disease Models, Animal
 Inflammation Antibodies  >9 publications with EDNRB and Inflammation
 Lung Diseases Antibodies  >9 publications with EDNRB and Lung Diseases
 Urinary Bladder Neoplasms Antibodies  >8 publications with EDNRB and Urinary Bladder Neoplasms
 Neoplasms, Experimental Antibodies  >8 publications with EDNRB and Neoplasms, Experimental
 Hypertension Antibodies  >6 publications with EDNRB and Hypertension
 Cardiovascular Diseases Antibodies  >6 publications with EDNRB and Cardiovascular Diseases
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