NP_001182657.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,008 Da
NCBI Official Full Name
excitatory amino acid transporter 2 isoform 2
NCBI Official Synonym Full Names
solute carrier family 1 (glial high affinity glutamate transporter), member 2
NCBI Protein Information
excitatory amino acid transporter 2
UniProt Protein Name
Excitatory amino acid transporter 2
UniProt Synonym Protein Names
Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2
UniProt Synonym Gene Names
UniProt Entry Name
EAA2_HUMAN
NCBI Summary for EAAT2
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]
UniProt Comments for EAAT2
GLT1: an integral membrane protein belonging to the sodium:dicarboxylate (SDF) symporter family. Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by co-transporting sodium.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p13-p12
Cellular Component: membrane; plasma membrane; integral to membrane; axolemma
Molecular Function: protein binding; glutamate:sodium symporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity
Biological Process: response to drug; synaptic transmission; positive regulation of glucose import; L-glutamate import; telencephalon development; adult behavior; multicellular organism growth; cellular response to extracellular stimulus; response to wounding; multicellular organismal aging; ion transport; response to amino acid stimulus; transmembrane transport; visual behavior
Research Articles on EAAT2
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Products associated with EAAT2 elisa kit
Pathways associated with EAAT2 elisa kit
Diseases associated with EAAT2 elisa kit
Organs/Tissues associated with EAAT2 elisa kit
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