P70623
[Other Products]
UniProt Related Accession #
Molecular Weight
14,708 Da
NCBI Official Full Name
Fatty acid-binding protein, adipocyte
NCBI Official Synonym Full Names
fatty acid binding protein 4
NCBI Official Synonym Symbols
NCBI Protein Information
fatty acid-binding protein, adipocyte
UniProt Protein Name
Fatty acid-binding protein, adipocyte
UniProt Synonym Protein Names
Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4
UniProt Synonym Gene Names
UniProt Entry Name
FABP4_RAT
NCBI Summary for FABP4
intracellular lipid-binding protein; mediates fatty acid trafficking during lipolysis [RGD, Feb 2006]
UniProt Comments for FABP4
FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family.
Protein type: Lipid-binding
Cellular Component: cytoplasm; cytosol; lipid particle
Molecular Function: fatty acid binding; protein binding
Biological Process: brown fat cell differentiation; cholesterol homeostasis; cytokine production; fatty acid metabolic process; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of inflammatory response; response to drug; response to glucocorticoid stimulus; triacylglycerol catabolic process; white fat cell differentiation
Research Articles on FABP4
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Products associated with FABP4 elisa kit
Pathways associated with FABP4 elisa kit
Organs/Tissues associated with FABP4 elisa kit
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