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FRS3 elisa kit :: Rat FRS3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2510438
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   

Rat FRS3 (Fibroblast Growth Factor Receptor Substrate 3) ELISA Kit

 Product Gene Name   

FRS3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    607744
 3D Structure    ModBase 3D Structure for O43559
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Rat FRS3. No significant cross-reactivity or interference between Rat FRS3 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Rat FRS3 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FRS3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FRS3 purchase    MBS2510438 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the FRS3, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing FRS3, with an estimated sensitivity of Min: 0.094ng/mL; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2510438 kit is based on FRS3 antibody-FRS3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FRS3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FRS3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for FRS3 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of FRS3 in Rat serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat FRS3. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Rat FRS3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat FRS3, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Rat FRS3. You can calculate the concentration of Rat FRS3 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of FRS3 elisa kit    FRS3 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2510438. Click to request current manual
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NCBI/Uniprot data below describe general gene information for FRS3. It may not necessarily be applicable to this product.
 NCBI GI #    5730059
 NCBI GeneID    10817
 NCBI Accession #    NP_006644.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006653.4 [Other Products]
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 UniProt Primary Accession #    O43559 [Other Products]
 UniProt Secondary Accession #    Q5T3D5 [Other Products]
 UniProt Related Accession #    O43559 [Other Products]
 Molecular Weight    54,462 Da
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 NCBI Official Full Name    fibroblast growth factor receptor substrate 3
 NCBI Official Synonym Full Names    fibroblast growth factor receptor substrate 3
 NCBI Official Symbol    FRS3 [Similar Products]
 NCBI Official Synonym Symbols   
SNT2; FRS2B; SNT-2; FRS2beta; FRS2-beta
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor substrate 3; FGFR substrate 3; FGFR-signaling adaptor SNT2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor)
 UniProt Protein Name    Fibroblast growth factor receptor substrate 3
 UniProt Synonym Protein Names   
FGFR-signaling adaptor SNT2; Suc1-associated neurotrophic factor target 2; SNT-2
 Protein Family    Fibroblast growth factor receptor substrate
 UniProt Gene Name    FRS3 [Similar Products]
 UniProt Synonym Gene Names    FGFR substrate 3; SNT-2 [Similar Products]
 UniProt Entry Name    FRS3_HUMAN
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 NCBI Summary for FRS3    This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
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 UniProt Comments for FRS3    FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Molecular Function: protein binding; insulin receptor binding; fibroblast growth factor receptor binding

Biological Process: fibroblast growth factor receptor signaling pathway; signal transduction
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 Research Articles on FRS3    1. Mechanisms by which FRS2beta acts as a feedback inhibitor of EGFR family members and suggest a role for FRS2beta as a tumor suppressor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FRS3 elisa kitPathways associated with FRS3 elisa kit
 Reference Product  PubMed Publications
 FRS2 elisa kit  >15 publications with FRS3 and FRS2
 GRB2 elisa kit  >7 publications with FRS3 and GRB2
 FGFR1 elisa kit  >6 publications with FRS3 and FGFR1
 PTPN11 elisa kit  >4 publications with FRS3 and PTPN11
 GAB2 elisa kit  >2 publications with FRS3 and GAB2
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FRS2-mediated Cascade Pathway antibodies  FRS2-mediated Cascade Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By FGFR Pathway antibodies  Signaling By FGFR Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
Diseases associated with FRS3 elisa kitOrgans/Tissues associated with FRS3 elisa kit
 Disease Name  Pubmed Publications
 Neural Tube Defects Antibodies  >1 publications with FRS3 and Neural Tube Defects
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with FRS3 and Brain
 Embryonic Tissue Antibodies  >3 publications with FRS3 and Embryonic Tissue
 Intestine Antibodies  >1 publications with FRS3 and Intestine
 Lung Antibodies  >1 publications with FRS3 and Lung
 Eye Antibodies  >1 publications with FRS3 and Eye
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