NP_005242.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,719 Da
NCBI Official Full Name
forkhead box protein C2
NCBI Official Synonym Full Names
forkhead box C2
NCBI Protein Information
forkhead box protein C2
UniProt Protein Name
Forkhead box protein C2
UniProt Synonym Protein Names
Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14
UniProt Synonym Gene Names
UniProt Entry Name
FOXC2_HUMAN
NCBI Summary for Foxc2
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
UniProt Comments for Foxc2
FOXC2: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2); also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment. Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN). LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD). LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).
Protein type: Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: nucleus
Molecular Function: chromatin DNA binding; identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: heart development; insulin receptor signaling pathway; lymphangiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to hormone stimulus
Disease: Lymphedema-distichiasis Syndrome
Research Articles on Foxc2
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Products associated with Foxc2 elisa kit
Pathways associated with Foxc2 elisa kit
Diseases associated with Foxc2 elisa kit
Organs/Tissues associated with Foxc2 elisa kit
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