EAW92803.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,696 Da
NCBI Official Full Name
glucosidase, beta, acid 3 (cytosolic), isoform CRA_b
NCBI Official Synonym Full Names
glucosidase, beta, acid 3
NCBI Protein Information
cytosolic beta-glucosidase; klotho-related protein; glucosidase, beta, acid 3 (cytosolic); cytosolic beta-glucosidase-like protein 1
UniProt Protein Name
Cytosolic beta-glucosidase
UniProt Synonym Protein Names
Cytosolic beta-glucosidase-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
GBA3_HUMAN
NCBI Summary for GbetaA
The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013]
UniProt Comments for GbetaA
GBA3: Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; EC 3.2.1.21; Other Amino Acids Metabolism - cyanoamino acid; Carbohydrate Metabolism - starch and sucrose
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: cytosol
Molecular Function: beta-glucosidase activity; beta-galactosidase activity; glycosylceramidase activity
Biological Process: sphingolipid metabolic process; glycoside catabolic process; carbohydrate metabolic process; glycosylceramide catabolic process; glycosphingolipid metabolic process
Research Articles on GbetaA
Precautions
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Disclaimer
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Pathways associated with GbetaA elisa kit
Diseases associated with GbetaA elisa kit
Organs/Tissues associated with GbetaA elisa kit
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