NP_112293.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,242 Da
NCBI Official Full Name
glycine amidinotransferase, mitochondrial
NCBI Official Synonym Full Names
glycine amidinotransferase
NCBI Protein Information
glycine amidinotransferase, mitochondrial
UniProt Protein Name
Glycine amidinotransferase, mitochondrial
UniProt Synonym Protein Names
L-arginine:glycine amidinotransferase; Transamidinase
UniProt Synonym Gene Names
NCBI Summary for GATM
transamidinase enzyme that catalyzes creatine synthesis [RGD, Feb 2006]
UniProt Comments for GATM
GATM: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis. Defects in GATM are the cause of arginine:glycine amidinotransferase deficiency (AGAT deficiency). AGAT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in the brain. Belongs to the amidinotransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.4.1; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 3q35
Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function: amidinotransferase activity; glycine amidinotransferase activity
Biological Process: creatine biosynthetic process; creatine metabolic process; learning and/or memory; multicellular organism development; muscle atrophy; response to mercury ion; response to nutrient; response to organic substance; response to oxidative stress; response to peptide hormone; tissue regeneration
Research Articles on GATM
Precautions
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Pathways associated with GATM elisa kit
Diseases associated with GATM elisa kit
Organs/Tissues associated with GATM elisa kit
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