NP_001158188.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
87,317 Da
NCBI Official Full Name
glycogen phosphorylase, muscle form isoform 2
NCBI Official Synonym Full Names
phosphorylase, glycogen, muscle
NCBI Protein Information
glycogen phosphorylase, muscle form
UniProt Protein Name
Glycogen phosphorylase, muscle form
UniProt Synonym Protein Names
Myophosphorylase
UniProt Entry Name
PYGM_HUMAN
NCBI Summary for PYGM
This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
UniProt Comments for PYGM
PYGM: an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Phosphorylation of Ser-14 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Protein type: Carbohydrate Metabolism - starch and sucrose; Phosphorylase; EC 2.4.1.1; Transferase; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 11q12-q13.2
Cellular Component: cytoplasm; cytosol; sarcoplasmic reticulum
Molecular Function: AMP binding; carbohydrate binding; drug binding; glycogen phosphorylase activity; protein binding; pyridoxal phosphate binding
Biological Process: carbohydrate metabolic process; cellular calcium ion homeostasis; glucose metabolic process; glycogen catabolic process; glycogen metabolic process; response to cAMP; response to hypoxia
Disease: Glycogen Storage Disease V
Research Articles on PYGM
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with PYGM elisa kit
Pathways associated with PYGM elisa kit
Diseases associated with PYGM elisa kit
Organs/Tissues associated with PYGM elisa kit
|