NP_001035757.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,952 Da
NCBI Official Full Name
heat shock factor protein 4 isoform b
NCBI Official Synonym Full Names
heat shock transcription factor 4
NCBI Official Synonym Symbols
NCBI Protein Information
heat shock factor protein 4
UniProt Protein Name
Heat shock factor protein 4
UniProt Synonym Protein Names
Heat shock transcription factor 4; HSTF 4
UniProt Synonym Gene Names
UniProt Entry Name
HSF4_HUMAN
NCBI Summary for HSF4
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for HSF4
HSF4: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. Defects in HSF4 are the cause of cataract, zonular (CZ). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in HSF4 are the cause of cataract Marner type (CAM). A form of cataract with variable and progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar, or stellate cataract. Finger malformation is observed in some kindreds. Belongs to the HSF family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: nucleoplasm
Molecular Function: protein phosphatase binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity
Biological Process: camera-type eye development; cell development; histone H3-K9 demethylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Disease: Cataract 5, Multiple Types
Research Articles on HSF4
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Products associated with HSF4 elisa kit
Diseases associated with HSF4 elisa kit
Disease Name |
Pubmed Publications |
Disease Models, Animal Antibodies |
>7 publications with HSF4 and Disease Models, Animal |
Congenital Abnormalities Antibodies |
>3 publications with HSF4 and Congenital Abnormalities |
Cell Transformation, Neoplastic Antibodies |
>3 publications with HSF4 and Cell Transformation, Neoplastic |
Lung Neoplasms Antibodies |
>2 publications with HSF4 and Lung Neoplasms |
Inflammation Antibodies |
>2 publications with HSF4 and Inflammation |
Cataract, zonular Antibodies |
>2 publications with HSF4 and Cataract, zonular |
Abnormalities, Drug-Induced Antibodies |
>1 publications with HSF4 and Abnormalities, Drug-Induced |
Aneuploidy Antibodies |
>1 publications with HSF4 and Aneuploidy |
Chromosome Aberrations Antibodies |
>1 publications with HSF4 and Chromosome Aberrations |
Neoplasms, Experimental Antibodies |
>1 publications with HSF4 and Neoplasms, Experimental |
Organs/Tissues associated with HSF4 elisa kit
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