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ICAM1 elisa kit :: Rat ICAM-1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS175919
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $455 +1 FREE 8GB USB
 
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 Product Name   

ICAM-1 (ICAM1), ELISA Kit

★Popular Item★
 Also Known As   

Rat ICAM-1 PicoKine ELISA Kit

 Product Synonym Names    Intercellular adhesion molecule 1; intercellular adhesion molecule 1; BB2; CD 54; CD54; CD54 antigen; Cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM 1; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MGC6195; MyD10; P3.58; Surface antigen of activated B cells
 Product Gene Name   

ICAM1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 611162
 3D Structure    ModBase 3D Structure for P05362
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 Species Reactivity    Rat
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 Specificity    Natural and recombinant rat ICAM-1
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 Samples    Cell culture supernates, serum and plasma (heparin, EDTA)
 Assay Type    Sandwich
 Detection Range    31.2pg/ml-2000pg/ml
 Sensitivity    < 2pg/ml
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ICAM1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ICAM1 purchase    MBS175919 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ICAM-1 (ICAM1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2pg/ml-2000pg/ml in biological research samples containing ICAM1, with an estimated sensitivity of < 2pg/ml. The ELISA analytical biochemical technique of the MBS175919 kit is based on ICAM1 antibody-ICAM1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ICAM1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ICAM1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, serum and plasma (heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ICAM1 elisa kit

   Principle of the assay: rat ICAM-1 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for ICAM-1 has been precoated onto 96-well plates. Standards(NSO,Q28 - T493) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for ICAM-1 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the rat ICAM-1 amount of sample captured in plate.
Background: Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for lymphocyte function-associated (LFA) antigens, a beta 2 leukocyte integrin.1 Thenormal function of human intercellular adhesion molecule-1 (ICAM-1) is to provide adhesion between endothelial cells and leukocytes after injury or stress. ICAM-1 binds to leukocyte function-associated antigen (LFA-1) or macrophage-1 antigen (Mac-1).2 ICAM-1 is found on leukocytes, fibroblasts, epithelial cells and endothelial cellsand its expression is regulated by inflammatory cytokines.3 ICAM-1 has a tissue distribution similar to that of themajor histocompatibility complex class II antigens and is likely to play a role in inflammatory responses.1 Thestandard product used in this kit is produced by recombinant gene expression, which is a dimeric protein linked with disulfide bonds.
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 Typical Testing Data/Standard Curve (for reference only) of ICAM1 elisa kit    Rat ICAM-1 PicoKine ELISA Kit standard curve
ICAM1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS175919. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ICAM1. It may not necessarily be applicable to this product.
 NCBI GI #    68067956
 NCBI GeneID    3383
 NCBI Accession #    P05362.2 [Other Products]
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 UniProt Primary Accession #    P05362 [Other Products]
 UniProt Secondary Accession #    Q5NKV7; Q96B50; B2R6M3 [Other Products]
 UniProt Related Accession #    P05362 [Other Products]
 Molecular Weight    57,825 Da
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 NCBI Official Full Name    Intercellular adhesion molecule 1
 NCBI Official Synonym Full Names    intercellular adhesion molecule 1
 NCBI Official Symbol    ICAM1 [Similar Products]
 NCBI Official Synonym Symbols   
BB2; CD54; P3.58
[Similar Products]
 NCBI Protein Information    intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
 UniProt Protein Name    Intercellular adhesion molecule 1
 UniProt Synonym Protein Names   
Major group rhinovirus receptor; CD_antigen: CD54
 Protein Family    Intercellular adhesion molecule
 UniProt Gene Name    ICAM1 [Similar Products]
 UniProt Synonym Gene Names    ICAM-1 [Similar Products]
 UniProt Entry Name    ICAM1_HUMAN
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 NCBI Summary for ICAM1    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ICAM1    ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Cell adhesion; Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane

Molecular Function: integrin binding; viral receptor activity; protein binding; transmembrane receptor activity; receptor activity

Biological Process: extracellular matrix organization and biogenesis; entry of virus into host cell; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; regulation of cell adhesion; response to drug; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; positive regulation of actin filament polymerization; response to copper ion; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration

Disease: Malaria, Susceptibility To
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 Research Articles on ICAM1    1. NF-kappaB/ICAM-1 pathway induced adhesion of neutrophils and was involved in renal injury after hypoxia-ischemia injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ICAM1 elisa kitPathways associated with ICAM1 elisa kit
 Reference Product  PubMed Publications
 ITGB2 elisa kit  >879 publications with ICAM1 and ITGB2
 ITGAL elisa kit  >472 publications with ICAM1 and ITGAL
 ITGAM elisa kit  >437 publications with ICAM1 and ITGAM
 CD44 elisa kit  >368 publications with ICAM1 and CD44
 IL6 elisa kit  >146 publications with ICAM1 and IL6
 ITGAX elisa kit  >139 publications with ICAM1 and ITGAX
 SELE elisa kit  >78 publications with ICAM1 and SELE
 HLA-B elisa kit  >29 publications with ICAM1 and HLA-B
 DIF elisa kit  >3 publications with ICAM1 and DIF
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
Diseases associated with ICAM1 elisa kitOrgans/Tissues associated with ICAM1 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5522 publications with ICAM1 and Inflammation
 Necrosis Antibodies  >4728 publications with ICAM1 and Necrosis
 Cardiovascular Diseases Antibodies  >3578 publications with ICAM1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1433 publications with ICAM1 and Atherosclerosis
 Reperfusion Injury Antibodies  >873 publications with ICAM1 and Reperfusion Injury
 Myocardial Ischemia Antibodies  >787 publications with ICAM1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >751 publications with ICAM1 and Kidney Diseases
 Liver Diseases Antibodies  >544 publications with ICAM1 and Liver Diseases
 Hypertension Antibodies  >517 publications with ICAM1 and Hypertension
 Asthma Antibodies  >500 publications with ICAM1 and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11657 publications with ICAM1 and Blood
 Vascular Antibodies  >8711 publications with ICAM1 and Vascular
 Lung Antibodies  >1750 publications with ICAM1 and Lung
 Heart Antibodies  >1266 publications with ICAM1 and Heart
 Skin Antibodies  >1191 publications with ICAM1 and Skin
 Liver Antibodies  >1171 publications with ICAM1 and Liver
 Kidney Antibodies  >1161 publications with ICAM1 and Kidney
 Brain Antibodies  >1157 publications with ICAM1 and Brain
 Muscle Antibodies  >1028 publications with ICAM1 and Muscle
 Embryonic Tissue Antibodies  >770 publications with ICAM1 and Embryonic Tissue
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