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IDS elisa kit :: Rat IDS ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2512648
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IDS, ELISA Kit

★Popular Item★
 Also Known As   

Rat IDS (Iduronate Sulfatase) ELISA Kit

 Product Gene Name   

IDS elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    300823
 3D Structure    ModBase 3D Structure for P22304
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 Species Reactivity    Rat
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 Specificity    This kit recognizes natural and recombinant Rat IDS. No significant cross-reactivity or interference between Rat IDS and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    1.563-100ng/mL
 Sensitivity    Min: 0.938ng/mL; Max: 100ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IDS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IDS purchase    MBS2512648 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the IDS, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.563-100ng/mL in biological research samples containing IDS, with an estimated sensitivity of Min: 0.938ng/mL; Max: 100ng/mL. The ELISA analytical biochemical technique of the MBS2512648 kit is based on IDS antibody-IDS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IDS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IDS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IDS elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Rat IDS concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to IDS. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for IDS and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain IDS, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of IDS. You can calculate the concentration of IDS in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of IDS elisa kit    IDS elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2512648. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IDS. It may not necessarily be applicable to this product.
 NCBI GI #    4557659
 NCBI GeneID    3423
 NCBI Accession #    NP_000193.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000202.6 [Other Products]
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 UniProt Primary Accession #    P22304 [Other Products]
 UniProt Secondary Accession #    Q14604; Q9BRM3; D3DWT4 [Other Products]
 UniProt Related Accession #    P22304 [Other Products]
 Molecular Weight    34,893 Da
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 NCBI Official Full Name    iduronate 2-sulfatase isoform a preproprotein
 NCBI Official Synonym Full Names    iduronate 2-sulfatase
 NCBI Official Symbol    IDS [Similar Products]
 NCBI Official Synonym Symbols   
MPS2; SIDS
[Similar Products]
 NCBI Protein Information    iduronate 2-sulfatase; alpha-L-iduronate sulfate sulfatase; iduronate 2-sulfatase 14 kDa chain; iduronate 2-sulfatase 42 kDa chain; idursulfase
 UniProt Protein Name    Iduronate 2-sulfatase
 UniProt Synonym Protein Names   
Alpha-L-iduronate sulfate sulfatase; Idursulfase
 Protein Family    Iduronate 2-sulfatase
 UniProt Gene Name    IDS [Similar Products]
 UniProt Synonym Gene Names    SIDS; Idursulfase [Similar Products]
 UniProt Entry Name    IDS_HUMAN
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 NCBI Summary for IDS    The protein encoded by this gene belongs to the sulfatase family, is localized to the lysosome, and is involved in lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease, mucopolysaccharidosis type II, also known as Hunter syndrome. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2013]
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 UniProt Comments for IDS    IDS: Required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Defects in IDS are the cause of mucopolysaccharidosis type 2 (MPS2); also known as Hunter syndrome. MPS2 is an X-linked lysosomal storage disease characterized by intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine. Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration. A prominent feature is neurological damage that presents as developmental delay and hyperactivity but progresses to mental retardation and dementia. They die before 15 years of age, usually as a result of obstructive airway disease or cardiac failure. In contrast, those with a mild form of MPS2 may survive into adulthood, with attenuated somatic complications and often without mental retardation. Belongs to the sulfatase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - glycosaminoglycan degradation; EC 3.1.6.13; Hydrolase

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: lysosomal lumen

Molecular Function: iduronate-2-sulfatase activity; metal ion binding

Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; chondroitin sulfate catabolic process; pathogenesis

Disease: Mucopolysaccharidosis, Type Ii
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 Research Articles on IDS    1. This study evaluated a novel mutation in the IDS gene among 8 male Hunter syndrome patients; there was a quantitative deficiency of NK and B cell with normal responses in other immune parameters.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IDS elisa kitPathways associated with IDS elisa kit
 Reference Product  PubMed Publications
 IDUA elisa kit  >6 publications with IDS and IDUA
 ARSB elisa kit  >4 publications with IDS and ARSB
 HEXA elisa kit  >2 publications with IDS and HEXA
 SUMF1 elisa kit  >1 publications with IDS and SUMF1
 HPSE elisa kit  >1 publications with IDS and HPSE
 NAGLU elisa kit  >1 publications with IDS and NAGLU
 Products by Pathway  Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
Diseases associated with IDS elisa kitOrgans/Tissues associated with IDS elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >384 publications with IDS and Nervous System Diseases
 Mucopolysaccharidosis II Antibodies  >204 publications with IDS and Mucopolysaccharidosis II
 Ovarian Neoplasms Antibodies  >59 publications with IDS and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >59 publications with IDS and Ovarian Diseases
 Brain Diseases Antibodies  >54 publications with IDS and Brain Diseases
 Inflammation Antibodies  >49 publications with IDS and Inflammation
 Congenital Abnormalities Antibodies  >43 publications with IDS and Congenital Abnormalities
 Kidney Diseases Antibodies  >38 publications with IDS and Kidney Diseases
 Disease Models, Animal Antibodies  >37 publications with IDS and Disease Models, Animal
 Liver Diseases Antibodies  >27 publications with IDS and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >353 publications with IDS and Blood
 Brain Antibodies  >113 publications with IDS and Brain
 Bone Antibodies  >96 publications with IDS and Bone
 Heart Antibodies  >68 publications with IDS and Heart
 Muscle Antibodies  >59 publications with IDS and Muscle
 Liver Antibodies  >54 publications with IDS and Liver
 Kidney Antibodies  >47 publications with IDS and Kidney
 Vascular Antibodies  >40 publications with IDS and Vascular
 Mouth Antibodies  >35 publications with IDS and Mouth
 Skin Antibodies  >34 publications with IDS and Skin
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