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IL-23 elisa kit :: Rat IL-23 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2503662
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-23, ELISA Kit

★Popular Item★
 Also Known As   

Rat IL-23 (Interleukin 23) ELISA Kit

 Product Gene Name   

IL-23 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2503662 COA    COA PDF
 OMIM    605580
 3D Structure    ModBase 3D Structure for Q9NPF7
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 Species Reactivity    Rat
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 Specificity    This kit recognizes natural and some recombinant Rat IL-23. No significant crossreactivity or interference between Rat IL-23 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    15.63-1000 pg/mL
 Sensitivity    9.38 pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IL-23 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IL-23 purchase    MBS2503662 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the IL-23, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.63-1000 pg/mL in biological research samples containing IL-23, with an estimated sensitivity of 9.38 pg/mL. The ELISA analytical biochemical technique of the MBS2503662 kit is based on IL-23 antibody-IL-23 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IL-23 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IL-23. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IL-23 elisa kit

   Intended Uses: This ELISA kit can be applied to the in vitro quantitative determination of Rat IL-23 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been precoated with an antibody specific to Rat IL-23. Standards or samples are added to appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibodies specific for Rat IL-23 and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. After incubation, free components are washed away. Then the Substrate Reagent is added to each well, only those wells that contain Rat IL-23, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction will be terminated by adding Stop Solution and appears yellow in color. The optical density (OD) can be measured with spectrophotometry at a wavelength of 450 nm 2 nm. The OD value is proportional to the concentration of Rat IL-23. The concentration of Rat IL-23 in samples can be calculated by comparing the OD of the samples with the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of IL-23 elisa kit    IL-23 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2503662. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IL-23. It may not necessarily be applicable to this product.
 NCBI GI #    7706702
 NCBI GeneID    51561
 NCBI Accession #    NP_057668.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016584.2 [Other Products]
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 UniProt Primary Accession #    Q9NPF7 [Other Products]
 UniProt Secondary Accession #    Q6NZ80; Q6NZ82; Q9H2A5 [Other Products]
 UniProt Related Accession #    Q9NPF7 [Other Products]
 Molecular Weight    20,730 Da
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 NCBI Official Full Name    interleukin-23 subunit alpha
 NCBI Official Synonym Full Names    interleukin 23, alpha subunit p19
 NCBI Official Symbol    IL23A [Similar Products]
 NCBI Official Synonym Symbols   
P19; SGRF; IL-23; IL-23A; IL23P19
[Similar Products]
 NCBI Protein Information    interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; IL-23p19; JKA3 induced upon T-cell activation; interleukin 23 p19 subunit; interleukin-23 subunit p19; interleukin-six, G-CSF related factor
 UniProt Protein Name    Interleukin-23 subunit alpha
 UniProt Synonym Protein Names   
Interleukin-23 subunit p19; IL-23p19
 UniProt Gene Name    IL23A [Similar Products]
 UniProt Synonym Gene Names    SGRF; IL-23 subunit alpha; IL-23-A; IL-23p19 [Similar Products]
 UniProt Entry Name    IL23A_HUMAN
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 NCBI Summary for IL-23    This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL-23    IL23A: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Belongs to the IL-6 superfamily.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 12q13.3

Molecular Function: protein binding; cytokine activity; interleukin-23 receptor binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of T-helper 1 type immune response; negative regulation of interleukin-10 production; positive regulation of osteoclast differentiation; positive regulation of interleukin-12 production; positive regulation of T cell mediated cytotoxicity; tissue remodeling; positive regulation of NK T cell proliferation; positive regulation of tyrosine phosphorylation of Stat4 protein; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; defense response to Gram-negative bacterium; positive regulation of interleukin-10 production; positive regulation of natural killer cell activation; positive regulation of tyrosine phosphorylation of Stat3 protein; T cell proliferation; positive regulation of T cell proliferation; inflammatory response; defense response to virus; positive regulation of memory T cell differentiation; positive regulation of interleukin-17 production; positive regulation of NK T cell activation; positive regulation of natural killer cell proliferation; positive regulation of tumor necrosis factor production; regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of Stat5 protein; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; positive regulation of inflammatory response
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 Research Articles on IL-23    1. preoperative serum IL23 has no outcome prognostic value in patients with colorectal cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL-23 elisa kitPathways associated with IL-23 elisa kit
 Reference Product  PubMed Publications
 IL17A elisa kit  >69 publications with IL-23 and IL17A
 CD4 elisa kit  >65 publications with IL-23 and CD4
 IL12B elisa kit  >32 publications with IL-23 and IL12B
 IL23R elisa kit  >27 publications with IL-23 and IL23R
 IL12RB1 elisa kit  >17 publications with IL-23 and IL12RB1
 IL6 elisa kit  >15 publications with IL-23 and IL6
 STAT3 elisa kit  >11 publications with IL-23 and STAT3
 IL1B elisa kit  >6 publications with IL-23 and IL1B
 SOCS3 elisa kit  >5 publications with IL-23 and SOCS3
 IFNG elisa kit  >2 publications with IL-23 and IFNG
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
Diseases associated with IL-23 elisa kitOrgans/Tissues associated with IL-23 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >84 publications with IL-23 and Inflammation
 Gastrointestinal Diseases Antibodies  >41 publications with IL-23 and Gastrointestinal Diseases
 Necrosis Antibodies  >38 publications with IL-23 and Necrosis
 Disease Models, Animal Antibodies  >38 publications with IL-23 and Disease Models, Animal
 Skin Diseases Antibodies  >37 publications with IL-23 and Skin Diseases
 Psoriasis Antibodies  >31 publications with IL-23 and Psoriasis
 Nervous System Diseases Antibodies  >26 publications with IL-23 and Nervous System Diseases
 Lung Diseases Antibodies  >17 publications with IL-23 and Lung Diseases
 Carcinoma Antibodies  >13 publications with IL-23 and Carcinoma
 Bone Marrow Diseases Antibodies  >6 publications with IL-23 and Bone Marrow Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >166 publications with IL-23 and Blood
 Skin Antibodies  >29 publications with IL-23 and Skin
 Bone Antibodies  >28 publications with IL-23 and Bone
 Bone Marrow Antibodies  >25 publications with IL-23 and Bone Marrow
 Lung Antibodies  >22 publications with IL-23 and Lung
 Intestine Antibodies  >21 publications with IL-23 and Intestine
 Lymph Node Antibodies  >13 publications with IL-23 and Lymph Node
 Spleen Antibodies  >13 publications with IL-23 and Spleen
 Lymph Antibodies  >12 publications with IL-23 and Lymph
 Liver Antibodies  >11 publications with IL-23 and Liver
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