NP_002184.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,122 Da
NCBI Official Full Name
inhibin beta B chain preproprotein
NCBI Official Synonym Full Names
inhibin, beta B
NCBI Protein Information
inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide
UniProt Protein Name
Inhibin beta B chain
UniProt Synonym Protein Names
Activin beta-B chain
UniProt Entry Name
INHBB_HUMAN
NCBI Summary for INH-B
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
UniProt Comments for INH-B
INHBB: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation; Cytokine
Chromosomal Location of Human Ortholog: 2cen-q13
Cellular Component: extracellular space; perinuclear region of cytoplasm; extracellular region
Molecular Function: protein binding; protein homodimerization activity; growth factor activity; hormone activity; cytokine activity; host cell surface receptor binding; transforming growth factor beta receptor binding
Biological Process: fat cell differentiation; activin receptor signaling pathway; defense response; negative regulation of hepatocyte growth factor biosynthetic process; cellular response to starvation; negative regulation of insulin secretion; negative regulation of follicle-stimulating hormone secretion; regulation of apoptosis; cellular response to insulin stimulus; ovarian follicle development; response to mechanical stimulus; regulation of MAPKKK cascade; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell development; oocyte development; growth
Research Articles on INH-B
Precautions
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Products associated with INH-B elisa kit
Pathways associated with INH-B elisa kit
Organs/Tissues associated with INH-B elisa kit
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