EAW94141
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,442 Da
NCBI Official Full Name
inhibin, beta A (activin A, activin AB alpha polypeptide), isoform CRA_a
NCBI Official Synonym Full Names
inhibin, beta A
NCBI Official Synonym Symbols
NCBI Protein Information
inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; inhibin, beta A (activin A, activin AB alpha polypeptide)
UniProt Protein Name
Inhibin beta A chain
UniProt Synonym Protein Names
Activin beta-A chain; Erythroid differentiation protein
UniProt Synonym Gene Names
UniProt Entry Name
INHBA_HUMAN
NCBI Summary for INB-betaA
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]
UniProt Comments for INB-betaA
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subunit structure: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3. Ref.8
Subcellular location: Secreted.
Sequence similarities: Belongs to the TGF-beta family.
Research Articles on INB-betaA
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Products associated with INB-betaA elisa kit
Pathways associated with INB-betaA elisa kit
Diseases associated with INB-betaA elisa kit
Organs/Tissues associated with INB-betaA elisa kit
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