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ILK-1 elisa kit :: Rat Integrin-linked kinase1 (ILK-1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS267602 ILK-1 elisa kit
Unit / Price
48-Strip-Wells  /  $275 +1 FREE 8GB USB
96-Strip-Wells  /  $435 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,755 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,150 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin-linked kinase1 (ILK-1), ELISA Kit

★Popular Item★
 Also Known As   

Rat Integrin-linked kinase1 (ILK-1) ELISA Kit

 Product Gene Name   

ILK-1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    602366
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 Species Reactivity    Rat
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ILK-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ILK-1 purchase    MBS267602 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Integrin-linked kinase1 (ILK-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ILK-1. The ELISA analytical biochemical technique of the MBS267602 kit is based on ILK-1 antibody-ILK-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ILK-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ILK-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ILK-1. It may not necessarily be applicable to this product.
 NCBI GI #    510785742
 NCBI GeneID    3611
 NCBI Accession #    NP_001265371.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278442.1 [Other Products]
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 UniProt Secondary Accession #    P57043; Q68DZ3; B7Z418; D3DQU0 [Other Products]
 UniProt Related Accession #    Q13418 [Other Products]
 Molecular Weight    44,349 Da
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 NCBI Official Full Name    integrin-linked protein kinase isoform 3
 NCBI Official Synonym Full Names    integrin-linked kinase
 NCBI Official Symbol    ILK [Similar Products]
 NCBI Official Synonym Symbols   
P59; ILK-1; ILK-2; p59ILK; HEL-S-28
[Similar Products]
 NCBI Protein Information    integrin-linked protein kinase; integrin-linked kinase-2; epididymis secretory protein Li 28; 59 kDa serine/threonine-protein kinase
 UniProt Protein Name    Integrin-linked protein kinase
 UniProt Synonym Protein Names   
59 kDa serine/threonine-protein kinase; ILK-1; ILK-2; p59ILK
 UniProt Gene Name    ILK [Similar Products]
 UniProt Synonym Gene Names    ILK1; ILK2 [Similar Products]
 UniProt Entry Name    ILK_HUMAN
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 NCBI Summary for ILK-1    This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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 UniProt Comments for ILK-1    ILK: a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin, PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.1; Kinase, protein; TKL group; MLK family; ILK subfamily

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: focal adhesion; protein complex; costamere; terminal button; intercellular junction; cytosol; nucleoplasm; sarcomere; membrane; cell soma; lamellipodium; cytoplasm; plasma membrane; stress fiber; dendritic shaft; cell junction

Molecular Function: integrin binding; protein serine/threonine kinase activity; signal transducer activity; protein binding; SH3 domain binding; protein kinase binding; ATP binding

Biological Process: negative regulation of smooth muscle cell proliferation; protein heterooligomerization; positive regulation of transcription, DNA-dependent; positive regulation of axon extension; cell-matrix adhesion; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; myelin formation; positive regulation of MAP kinase activity; positive regulation of cell proliferation; fibril organization and biogenesis; protein kinase B signaling cascade; negative regulation of neuron apoptosis; positive regulation of cell-matrix adhesion; cell cycle arrest; positive regulation of BMP signaling pathway; integrin-mediated signaling pathway; cell aging; positive regulation of dendrite morphogenesis; positive regulation of myoblast differentiation; myelination in the peripheral nervous system; establishment and/or maintenance of epithelial cell polarity; positive regulation of protein kinase B signaling cascade; cell proliferation; positive regulation of osteoblast differentiation; peptidyl-serine phosphorylation; ureteric bud branching; regulation of actin cytoskeleton organization and biogenesis; negative regulation of protein kinase activity; nerve development; positive regulation of phosphorylation; neurite morphogenesis; positive regulation of cell migration
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 Research Articles on ILK-1    1. we conclude that the CRC cells survival and invasion enhanced by hypoxia are mediated by ILK, and ILK may be an important potential therapeutic target for CRC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ILK-1 elisa kitPathways associated with ILK-1 elisa kit
 Reference Product  PubMed Publications
 LIMS1 elisa kit  >47 publications with ILK-1 and LIMS1
 PARVA elisa kit  >41 publications with ILK-1 and PARVA
 AKT1 elisa kit  >36 publications with ILK-1 and AKT1
 PARVB elisa kit  >23 publications with ILK-1 and PARVB
 PXN elisa kit  >9 publications with ILK-1 and PXN
 LIMS2 elisa kit  >8 publications with ILK-1 and LIMS2
 RUVBL1 elisa kit  >2 publications with ILK-1 and RUVBL1
 IQGAP1 elisa kit  >2 publications with ILK-1 and IQGAP1
 ITGB1 elisa kit  >1 publications with ILK-1 and ITGB1
 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-extracellular Matrix Interactions Pathway antibodies  Cell-extracellular Matrix Interactions Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram
 Eukaryotic Transcription Initiation Pathway antibodies  Eukaryotic Transcription Initiation Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with ILK-1 elisa kitOrgans/Tissues associated with ILK-1 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >54 publications with ILK-1 and Cardiovascular Diseases
 Fibrosis Antibodies  >50 publications with ILK-1 and Fibrosis
 Kidney Diseases Antibodies  >43 publications with ILK-1 and Kidney Diseases
 Breast Neoplasms Antibodies  >35 publications with ILK-1 and Breast Neoplasms
 Heart Diseases Antibodies  >34 publications with ILK-1 and Heart Diseases
 Inflammation Antibodies  >32 publications with ILK-1 and Inflammation
 Liver Diseases Antibodies  >28 publications with ILK-1 and Liver Diseases
 Lung Diseases Antibodies  >27 publications with ILK-1 and Lung Diseases
 Lung Neoplasms Antibodies  >27 publications with ILK-1 and Lung Neoplasms
 Brain Diseases Antibodies  >21 publications with ILK-1 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >135 publications with ILK-1 and Muscle
 Vascular Antibodies  >104 publications with ILK-1 and Vascular
 Blood Antibodies  >96 publications with ILK-1 and Blood
 Kidney Antibodies  >92 publications with ILK-1 and Kidney
 Heart Antibodies  >62 publications with ILK-1 and Heart
 Embryonic Tissue Antibodies  >53 publications with ILK-1 and Embryonic Tissue
 Bone Antibodies  >43 publications with ILK-1 and Bone
 Lung Antibodies  >43 publications with ILK-1 and Lung
 Liver Antibodies  >38 publications with ILK-1 and Liver
 Brain Antibodies  >37 publications with ILK-1 and Brain
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