NP_036196.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,122 Da
NCBI Official Full Name
lens fiber major intrinsic protein
NCBI Official Synonym Full Names
major intrinsic protein of lens fiber
NCBI Official Synonym Symbols
AQP0; LIM1; MP26; MIP26; CTRCT15 [Similar Products]
NCBI Protein Information
lens fiber major intrinsic protein
UniProt Protein Name
Lens fiber major intrinsic protein
UniProt Synonym Protein Names
Aquaporin-0; MIP26; MP26
UniProt Synonym Gene Names
UniProt Entry Name
MIP_HUMAN
NCBI Summary for MIP
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]
UniProt Comments for MIP
AQP0: major intrinsic protein of lens fiber. A member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. May be responsible for regulating the osmolarity of the lens. Defects in MIP are a cause of autosomal recessive congenital cataract.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: apical plasma membrane; gap junction; integral to plasma membrane; intracellular canaliculus; intracellular membrane-bound organelle; plasma membrane
Molecular Function: calmodulin binding; glycerol channel activity; structural constituent of eye lens; transporter activity; water channel activity
Biological Process: canalicular bile acid transport; glycerol transport; lens development in camera-type eye; response to stimulus; transmembrane transport; visual perception; water transport
Disease: Cataract 15, Multiple Types
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