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LDLR elisa kit :: Rat Low Density Lipoprotein Receptor (LDLR) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS260387
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $290 +1 FREE 8GB USB
96-Strip-Wells  /  $450 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,755 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,150 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Low Density Lipoprotein Receptor (LDLR), ELISA Kit

 Also Known As   

Rat Low Density Lipoprotein Receptor (LDLR) ELISA Kit

 Product Gene Name   

LDLR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    606945
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 Species Reactivity    Rat
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 Specificity    No cross-reaction with other factors.
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 Samples    Rat serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant LDLR concentration
 Assay Type    Sandwich
 Detection Range    10 ng/ml-0.156 ng/ml
 Sensitivity    0.05 ng/ml.
 Intra-assay Precision    ? 8%
 Inter-assay Precision    ? 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LDLR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LDLR purchase    MBS260387 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Low Density Lipoprotein Receptor (LDLR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10 ng/ml-0.156 ng/ml in biological research samples containing LDLR, with an estimated sensitivity of 0.05 ng/ml. The ELISA analytical biochemical technique of the MBS260387 kit is based on LDLR antibody-LDLR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LDLR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LDLR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Rat serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant LDLR concentration. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for LDLR elisa kit

   Principle of the assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Rat LDLR monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of LDLR elisa kit    LDLR elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS260387. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LDLR. It may not necessarily be applicable to this product.
 NCBI GI #    307121
 NCBI GeneID    3949
 NCBI Accession #    AAA56833.1 [Other Products]
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 UniProt Secondary Accession #    Q53ZD9; Q59FQ1; Q9UDH7; B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7 [Other Products]
 UniProt Related Accession #    P01130 [Other Products]
 Molecular Weight    82,255 Da
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 NCBI Official Full Name    low density lipoprotein receptor
 NCBI Official Synonym Full Names    low density lipoprotein receptor
 NCBI Official Symbol    LDLR [Similar Products]
 NCBI Official Synonym Symbols   
FH; FHC; LDLCQ2
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3
 UniProt Protein Name    Low-density lipoprotein receptor
 Protein Family    Low-density lipoprotein receptor
 UniProt Gene Name    LDLR [Similar Products]
 UniProt Synonym Gene Names    LDL receptor [Similar Products]
 UniProt Entry Name    LDLR_HUMAN
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 NCBI Summary for LDLR    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
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 UniProt Comments for LDLR    LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface; Receptor, misc.

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: Golgi apparatus; cell surface; membrane; lysosome; integral to plasma membrane; early endosome; late endosome; plasma membrane; endosome membrane; coated pit; receptor complex; external side of plasma membrane

Molecular Function: very-low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; protein binding; low-density lipoprotein binding; calcium ion binding; clathrin heavy chain binding; glycoprotein binding

Biological Process: phototransduction, visible light; receptor-mediated endocytosis; lipoprotein catabolic process; cholesterol metabolic process; cholesterol transport; viral reproduction; cholesterol absorption; endocytosis; lipoprotein metabolic process; cholesterol homeostasis; phospholipid transport; lipid metabolic process; retinoid metabolic process

Disease: Hypercholesterolemia, Familial
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 Research Articles on LDLR    1. present study demonstrates that the effect of APOE E4 on cognitive function depends on age and education.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LDLR elisa kitPathways associated with LDLR elisa kit
 Reference Product  PubMed Publications
 APOE elisa kit  >475 publications with LDLR and APOE
 APOB elisa kit  >368 publications with LDLR and APOB
 PCSK9 elisa kit  >248 publications with LDLR and PCSK9
 LDLRAP1 elisa kit  >25 publications with LDLR and LDLRAP1
 LIPC elisa kit  >14 publications with LDLR and LIPC
 MYLIP elisa kit  >10 publications with LDLR and MYLIP
 DAB1 elisa kit  >3 publications with LDLR and DAB1
 LRPAP1 elisa kit  >3 publications with LDLR and LRPAP1
 APOH elisa kit  >1 publications with LDLR and APOH
 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
Diseases associated with LDLR elisa kitOrgans/Tissues associated with LDLR elisa kit
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >953 publications with LDLR and Atherosclerosis
 Cardiovascular Diseases Antibodies  >842 publications with LDLR and Cardiovascular Diseases
 Hypercholesterolemia Antibodies  >743 publications with LDLR and Hypercholesterolemia
 Dyslipidemias Antibodies  >738 publications with LDLR and Dyslipidemias
 Hyperlipidemias Antibodies  >690 publications with LDLR and Hyperlipidemias
 HYPERCHOLESTEROLEMIA, FAMILIAL Antibodies  >491 publications with LDLR and HYPERCHOLESTEROLEMIA, FAMILIAL
 Hyperlipoproteinemia Type II Antibodies  >355 publications with LDLR and Hyperlipoproteinemia Type II
 Inflammation Antibodies  >234 publications with LDLR and Inflammation
 Coronary Artery Disease Antibodies  >227 publications with LDLR and Coronary Artery Disease
 Coronary Disease Antibodies  >226 publications with LDLR and Coronary Disease
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1059 publications with LDLR and Blood
 Liver Antibodies  >588 publications with LDLR and Liver
 Vascular Antibodies  >514 publications with LDLR and Vascular
 Heart Antibodies  >275 publications with LDLR and Heart
 Bone Antibodies  >191 publications with LDLR and Bone
 Muscle Antibodies  >171 publications with LDLR and Muscle
 Bone Marrow Antibodies  >160 publications with LDLR and Bone Marrow
 Brain Antibodies  >125 publications with LDLR and Brain
 Kidney Antibodies  >70 publications with LDLR and Kidney
 Ovary Antibodies  >58 publications with LDLR and Ovary
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