AAC03540.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,389 Da
NCBI Official Full Name
macrophage inflammatory protein 2 alpha, partial
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Synonym Symbols
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a [Similar Products]
NCBI Protein Information
C-X-C motif chemokine 2; gro-beta; MGSA beta; MIP2-alpha; GRO2 oncogene; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alpha
UniProt Synonym Gene Names
UniProt Entry Name
CXCL2_HUMAN
NCBI Summary for MIP-2
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
UniProt Comments for MIP-2
CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: extracellular space; extracellular region
Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding
Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; chemotaxis; inflammatory response; regulation of cell proliferation
Research Articles on MIP-2
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