ACA48258.2
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UniProt Related Accession #
Molecular Weight
3,557 Da
NCBI Official Full Name
mannose binding lectin, partial
NCBI Official Synonym Full Names
mannose-binding lectin (protein C) 2, soluble
NCBI Official Synonym Symbols
MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC [Similar Products]
NCBI Protein Information
mannose-binding protein C
UniProt Protein Name
Mannose binding lectin
UniProt Synonym Protein Names
Mannose binding lectin
UniProt Entry Name
B1PN75_HUMAN
NCBI Summary for MBL
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]
UniProt Comments for MBL
MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: extracellular space; cell surface; collagen; extracellular region
Molecular Function: mannose binding; protein binding; calcium ion binding; calcium-dependent protein binding; receptor binding
Biological Process: defense response to Gram-positive bacterium; killing by host of symbiont cells; positive regulation of phagocytosis; defense response to bacterium; acute-phase response; innate immune response; opsonization; response to oxidative stress; complement activation, lectin pathway; complement activation, classical pathway; negative regulation of viral reproduction; complement activation
Disease: Mannose-binding Protein Deficiency
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