NP_004762.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,387 Da
NCBI Official Full Name
matrix metalloproteinase-20 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 20
NCBI Protein Information
matrix metalloproteinase-20; enamel metalloproteinase; matrix metalloproteinase 20 (enamelysin)
UniProt Protein Name
Matrix metalloproteinase-20
UniProt Synonym Protein Names
Enamel metalloproteinase; Enamelysin
UniProt Synonym Gene Names
UniProt Entry Name
MMP20_HUMAN
NCBI Summary for MMP20
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]
UniProt Comments for MMP20
MMP20: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2). AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase M10A family.
Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.24.-
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region
Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; protein catabolic process; proteolysis
Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Research Articles on MMP20
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Products associated with MMP20 elisa kit
Pathways associated with MMP20 elisa kit
Diseases associated with MMP20 elisa kit
Organs/Tissues associated with MMP20 elisa kit
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