NP_036848.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
53,238 Da
NCBI Official Full Name
monocarboxylate transporter 1
NCBI Official Synonym Full Names
solute carrier family 16 (monocarboxylate transporter), member 1
NCBI Protein Information
monocarboxylate transporter 1
UniProt Protein Name
Monocarboxylate transporter 1
UniProt Synonym Protein Names
Solute carrier family 16 member 1
UniProt Synonym Gene Names
UniProt Entry Name
MOT1_RAT
NCBI Summary for Slc16a1
transports lactic acid and other monocarboxylic acids [RGD, Feb 2006]
UniProt Comments for Slc16a1
MCT1: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT); also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7); also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Protein type: Membrane protein, integral; Transporter; Mitochondrial; Membrane protein, multi-pass; Transporter, SLC family
Cellular Component: centrosome; integral to plasma membrane; membrane; mitochondrion; plasma membrane
Molecular Function: lactate transmembrane transporter activity; protein binding; protein homodimerization activity; symporter activity
Biological Process: behavioral response to nutrient; centrosome organization and biogenesis; glucose homeostasis; lipid metabolic process; regulation of insulin secretion; response to food
Research Articles on Slc16a1
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Products associated with Slc16a1 elisa kit
Pathways associated with Slc16a1 elisa kit
Diseases associated with Slc16a1 elisa kit
Organs/Tissues associated with Slc16a1 elisa kit
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