NP_036822.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
140,655 Da
NCBI Official Full Name
phosphatidylcholine translocator ABCB4
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 4
NCBI Official Synonym Symbols
NCBI Protein Information
phosphatidylcholine translocator ABCB4
UniProt Protein Name
Phosphatidylcholine translocator ABCB4
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 4
UniProt Entry Name
MDR3_RAT
NCBI Summary for Abcb4
energy-dependent efflux pump; may be involved in changes in bile formation in response to diabetes [RGD, Feb 2006]
UniProt Comments for Abcb4
ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described.
Protein type: Membrane protein, integral; Transporter; EC 3.6.3.44; Transporter, ABC family; Membrane protein, multi-pass; Hydrolase
Cellular Component: apical plasma membrane; clathrin-coated vesicle; cytoplasm; Golgi membrane; integral to membrane; intercellular canaliculus; lipid raft; membrane; plasma membrane
Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; phosphatidylcholine transmembrane transporter activity; protein binding; xenobiotic-transporting ATPase activity
Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; bile acid secretion; lipid homeostasis; multidrug transport; phospholipid translocation; phospholipid transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cholesterol transport; response to drug; response to glucocorticoid stimulus; transmembrane transport; xenobiotic transport
Research Articles on Abcb4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with Abcb4 elisa kit
Pathways associated with Abcb4 elisa kit
Diseases associated with Abcb4 elisa kit
Organs/Tissues associated with Abcb4 elisa kit
|