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Sirt2 elisa kit :: Rat NAD-dependent deacetylase sirtuin-2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2881347 Sirt2 elisa kit
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NAD-dependent deacetylase sirtuin-2 (Sirt2), ELISA Kit

 Also Known As   

Rat NAD-dependent deacetylase sirtuin-2 ELISA Kit

 Product Synonym Names    NAD-dependent deacetylase sirtuin-2; SIR2-like protein 2; Sirt2; Sir2l2
 Product Gene Name   

Sirt2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for Q5RJQ4
 Species Reactivity    Rat
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 Assay Type    Sandwich
 Detection Range    0.312-20 ng/mL
 Sensitivity    0.157 ng/mL
 Intra-Assay CV    <=4.8%
 Inter-Assay CV    <=8.2%
 Recovery    102%
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of Sirt2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Sirt2 purchase    MBS2881347 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NAD-dependent deacetylase sirtuin-2 (Sirt2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312-20 ng/mL in biological research samples containing Sirt2, with an estimated sensitivity of 0.157 ng/mL. The ELISA analytical biochemical technique of the MBS2881347 kit is based on Sirt2 antibody-Sirt2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Sirt2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Sirt2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for Sirt2. It may not necessarily be applicable to this product.
 NCBI GI #    56605812
 NCBI GeneID    361532
 NCBI Accession #    NP_001008369.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008368.1 [Other Products]
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 UniProt Primary Accession #    Q5RJQ4 [Other Products]
 UniProt Related Accession #    Q5RJQ4 [Other Products]
 Molecular Weight    39,319 Da
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 NCBI Official Full Name    NAD-dependent protein deacetylase sirtuin-2
 NCBI Official Synonym Full Names    sirtuin 2
 NCBI Official Symbol    Sirt2 [Similar Products]
 NCBI Protein Information    NAD-dependent protein deacetylase sirtuin-2
 UniProt Protein Name    NAD-dependent protein deacetylase sirtuin-2
 UniProt Synonym Protein Names   
Regulatory protein SIR2 homolog 2; SIR2-like protein 2
 Protein Family    NAD-dependent protein deacetylase
 UniProt Gene Name    Sirt2 [Similar Products]
 UniProt Synonym Gene Names    Sir2l2 [Similar Products]
 UniProt Entry Name    SIR2_RAT
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 UniProt Comments for Sirt2    SIRT2: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Belongs to the sirtuin family. Class I subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.-; Deacetylase

Cellular Component: centriole; centrosome; chromosome; cytoplasm; cytosol; growth cone; lateral loop; microtubule; midbody; myelin sheath; nuclear heterochromatin; nucleus; paranode region of axon; perikaryon; perinuclear region of cytoplasm; plasma membrane; spindle

Molecular Function: beta-tubulin binding; chromatin binding; histone acetyltransferase binding; histone deacetylase activity; histone deacetylase binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); protein deacetylase activity; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding

Biological Process: autophagy; cell division; cellular lipid catabolic process; central nervous system development; hepatocyte growth factor receptor signaling pathway; histone deacetylation; meiotic cell cycle; mitosis; myelination in the peripheral nervous system; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of protein catabolic process; negative regulation of striated muscle development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphoinositide 3-kinase cascade; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cell division; positive regulation of DNA binding; positive regulation of meiosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid deacetylation; protein kinase B signaling cascade; regulation of cell cycle; regulation of fat cell differentiation; regulation of myelination; substantia nigra development; transcription, DNA-dependent
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 Research Articles on Sirt2    1. Our study helps to elucidate the mechanism for the participation of aging in Parkinson's disease (PD) and suggests that substantia nigra SIRT2 may be involved in PD neurodegeneration
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Sirt2 elisa kitDiseases associated with Sirt2 elisa kit
 Reference Product  PubMed Publications
 Hdac6 elisa kit  >28 publications with Sirt2 and Hdac6
 Foxo1 elisa kit  >11 publications with Sirt2 and Foxo1
 Tp53 elisa kit  >4 publications with Sirt2 and Tp53
 Cdk5 elisa kit  >1 publications with Sirt2 and Cdk5
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >53 publications with Sirt2 and Neurodegenerative Diseases
 Brain Diseases Antibodies  >40 publications with Sirt2 and Brain Diseases
 Inflammation Antibodies  >34 publications with Sirt2 and Inflammation
 Necrosis Antibodies  >19 publications with Sirt2 and Necrosis
 Cardiovascular Diseases Antibodies  >17 publications with Sirt2 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >9 publications with Sirt2 and Lung Neoplasms
 Cognition Disorders Antibodies  >7 publications with Sirt2 and Cognition Disorders
 Breast Neoplasms Antibodies  >7 publications with Sirt2 and Breast Neoplasms
 Nerve Degeneration Antibodies  >6 publications with Sirt2 and Nerve Degeneration
 Heart Diseases Antibodies  >6 publications with Sirt2 and Heart Diseases
Organs/Tissues associated with Sirt2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >63 publications with Sirt2 and Brain
 Muscle Antibodies  >21 publications with Sirt2 and Muscle
 Lung Antibodies  >18 publications with Sirt2 and Lung
 Heart Antibodies  >15 publications with Sirt2 and Heart
 Adipose Tissue Antibodies  >12 publications with Sirt2 and Adipose Tissue
 Liver Antibodies  >11 publications with Sirt2 and Liver
 Kidney Antibodies  >10 publications with Sirt2 and Kidney
 Embryonic Tissue Antibodies  >6 publications with Sirt2 and Embryonic Tissue
 Artery Antibodies  >5 publications with Sirt2 and Artery
 Connective Tissue Antibodies  >5 publications with Sirt2 and Connective Tissue
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