NP_001137309.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,915 Da
NCBI Official Full Name
NADPH oxidase 4 isoform c
NCBI Official Synonym Full Names
NADPH oxidase 4
NCBI Protein Information
NADPH oxidase 4; kidney oxidase-1; kidney superoxide-producing NADPH oxidase; renal NAD(P)H-oxidase
UniProt Protein Name
NADPH oxidase 4
UniProt Synonym Protein Names
Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase
UniProt Synonym Gene Names
UniProt Entry Name
NOX4_HUMAN
NCBI Summary for NOX 4
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
UniProt Comments for NOX 4
NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; EC 1.6.3.-; Membrane protein, multi-pass; Membrane protein, integral; Nucleolus; Cell cycle regulation
Chromosomal Location of Human Ortholog: 11q14.2-q21
Cellular Component: endoplasmic reticulum membrane; focal adhesion; mitochondrion; perinuclear region of cytoplasm; apical plasma membrane; integral to membrane; stress fiber; nucleolus; NADPH oxidase complex
Molecular Function: FAD binding; electron carrier activity; oxygen sensor activity; NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; nucleotide binding; heme binding
Biological Process: positive regulation of apoptosis; cell morphogenesis; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; negative regulation of cell proliferation; positive regulation of stress fiber formation; response to hypoxia; inflammatory response; superoxide release; bone resorption
Research Articles on NOX 4
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Products associated with NOX 4 elisa kit
Pathways associated with NOX 4 elisa kit
Diseases associated with NOX 4 elisa kit
Organs/Tissues associated with NOX 4 elisa kit
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