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CANCA elisa kit :: Rat Neutrophil Cytoplasmic Antibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS009688 CANCA elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neutrophil Cytoplasmic Antibody (CANCA), ELISA Kit

 Also Known As   

Rat Neutrophil Cytoplasmic Antibody ELISA Kit

 Product Gene Name   

CANCA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P30152
 Species Reactivity    Rat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CANCA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CANCA purchase    MBS009688 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neutrophil Cytoplasmic Antibody (CANCA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CANCA. The ELISA analytical biochemical technique of the MBS009688 kit is based on CANCA antibody-CANCA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CANCA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CANCA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CANCA. It may not necessarily be applicable to this product.
 NCBI GI #    18543345
 NCBI GeneID    170496
 NCBI Accession #    NP_570097.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_130741.1 [Other Products]
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 UniProt Primary Accession #    P30152 [Other Products]
 UniProt Secondary Accession #    Q5HZF1 [Other Products]
 UniProt Related Accession #    P30152 [Other Products]
 Molecular Weight    22,476 Da
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 NCBI Official Full Name    neutrophil gelatinase-associated lipocalin
 NCBI Official Synonym Full Names    lipocalin 2
 NCBI Official Symbol    Lcn2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    neutrophil gelatinase-associated lipocalin; p25; NGAL; lipocalin-2; siderocalin LCN2; lipocalin 2 (oncogene 24p3); alpha-2U globulin-related protein; alpha-2-microglobulin-related protein
 UniProt Protein Name    Neutrophil gelatinase-associated lipocalin
 UniProt Synonym Protein Names   
Alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; Lipocalin-2; Siderocalin LCN2; p25
 UniProt Gene Name    Lcn2 [Similar Products]
 UniProt Synonym Gene Names    NGAL [Similar Products]
 UniProt Entry Name    NGAL_RAT
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 NCBI Summary for CANCA    mouse homolog plays a role in IL3 withdrawal-induced apoptosis [RGD, Feb 2006]
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 UniProt Comments for CANCA    LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Transporter; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding

Biological Process: response to nutrient levels; response to drug; cellular response to nutrient levels; iron ion homeostasis; response to mycotoxin; response to bacterium; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to oxidative stress; response to herbicide
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 Research Articles on CANCA    1. lipocalin-2 is released by injured neurons as a help me distress signal that activates microglia and astrocytes into potentially prorecovery phenotypes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CANCA elisa kitDiseases associated with CANCA elisa kit
 Reference Product  PubMed Publications
 Havcr1 elisa kit  >112 publications with CANCA and Havcr1
 Cst3 elisa kit  >39 publications with CANCA and Cst3
 Mmp9 elisa kit  >18 publications with CANCA and Mmp9
 Hmox1 elisa kit  >12 publications with CANCA and Hmox1
 S100a8 elisa kit  >10 publications with CANCA and S100a8
 S100a9 elisa kit  >10 publications with CANCA and S100a9
 Cxcl1 elisa kit  >9 publications with CANCA and Cxcl1
 Cxcl10 elisa kit  >8 publications with CANCA and Cxcl10
 Lbp elisa kit  >1 publications with CANCA and Lbp
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >553 publications with CANCA and Kidney Diseases
 Acute Kidney Injury Antibodies  >498 publications with CANCA and Acute Kidney Injury
 Renal Insufficiency Antibodies  >401 publications with CANCA and Renal Insufficiency
 Inflammation Antibodies  >252 publications with CANCA and Inflammation
 Neoplasms Antibodies  >189 publications with CANCA and Neoplasms
 Cardiovascular Diseases Antibodies  >186 publications with CANCA and Cardiovascular Diseases
 Heart Diseases Antibodies  >100 publications with CANCA and Heart Diseases
 Necrosis Antibodies  >88 publications with CANCA and Necrosis
 Proteinuria Antibodies  >77 publications with CANCA and Proteinuria
 Disease Models, Animal Antibodies  >76 publications with CANCA and Disease Models, Animal
Organs/Tissues associated with CANCA elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >127 publications with CANCA and Liver
 Heart Antibodies  >117 publications with CANCA and Heart
 Lung Antibodies  >70 publications with CANCA and Lung
 Connective Tissue Antibodies  >32 publications with CANCA and Connective Tissue
 Eye Antibodies  >12 publications with CANCA and Eye
 Pancreas Antibodies  >12 publications with CANCA and Pancreas
 Spleen Antibodies  >11 publications with CANCA and Spleen
 Ovary Antibodies  >10 publications with CANCA and Ovary
 Cervix Antibodies  >4 publications with CANCA and Cervix
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