NP_036993.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
22,244 Da
NCBI Official Full Name
methylated-DNA--protein-cysteine methyltransferase
NCBI Official Synonym Full Names
O-6-methylguanine-DNA methyltransferase
NCBI Protein Information
methylated-DNA--protein-cysteine methyltransferase; O6-alkylguanine-DNA alkyltransferase; O6-methylguanine-DNA methyltranferase; O-6-methylguanine-DNA-alkyltransferase; 0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase
UniProt Protein Name
Methylated-DNA--protein-cysteine methyltransferase
UniProt Synonym Protein Names
6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
MGMT_RAT
NCBI Summary for MGMT
enzyme involved in DNA repair of O(6)-alkylguanine which is the major mutagenic and carcinogenic lesion in DNA [RGD, Feb 2006]
UniProt Comments for MGMT
MGMT: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family.
Protein type: Nuclear receptor co-regulator; DNA repair, damage; EC 2.1.1.63; Apoptosis; Methyltransferase
Cellular Component: nucleoplasm; membrane; nucleus
Molecular Function: methyltransferase activity; methylated-DNA-[protein]-cysteine S-methyltransferase activity; damaged DNA binding; calcium ion binding
Biological Process: methylation; response to drug; positive regulation of DNA repair; response to ethanol; DNA dealkylation; response to toxin; response to folic acid; DNA repair; regulation of caspase activity; response to organic cyclic substance; response to DNA damage stimulus
Research Articles on MGMT
Precautions
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Pathways associated with MGMT elisa kit
Diseases associated with MGMT elisa kit
Organs/Tissues associated with MGMT elisa kit
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