NP_954642.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,963 Da
NCBI Official Full Name
osteocalcin preproprotein
NCBI Official Synonym Full Names
bone gamma-carboxyglutamate protein
NCBI Official Synonym Symbols
NCBI Protein Information
osteocalcin
UniProt Protein Name
Osteocalcin
UniProt Synonym Protein Names
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
UniProt Synonym Gene Names
NCBI Summary for OC
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
UniProt Comments for OC
osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.
Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasm; dendrite; endoplasmic reticulum lumen; extracellular space; Golgi lumen; perikaryon; rough endoplasmic reticulum; vesicle
Molecular Function: calcium ion binding; hydroxyapatite binding; structural constituent of bone; structural molecule activity
Biological Process: bone mineralization; cell adhesion; cell aging; ER to Golgi vesicle-mediated transport; odontogenesis; osteoblast development; osteoblast differentiation; peptidyl-glutamic acid carboxylation; regulation of bone mineralization; regulation of bone resorption; regulation of osteoclast differentiation; response to activity; response to drug; response to estrogen; response to ethanol; response to glucocorticoid stimulus; response to gravity; response to hydroxyisoflavone; response to mechanical stimulus; response to testosterone stimulus; response to vitamin D; response to vitamin K; response to zinc ion; signal peptide processing; skeletal system development
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Products associated with OC elisa kit
Pathways associated with OC elisa kit
Diseases associated with OC elisa kit
Organs/Tissues associated with OC elisa kit
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