NP_149126.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,167 Da
NCBI Official Full Name
platelet-derived growth factor D isoform 2
NCBI Official Synonym Full Names
platelet derived growth factor D
NCBI Protein Information
platelet-derived growth factor D; PDGF-D; iris-expressed growth factor; spinal cord derived growth factor B; spinal cord-derived growth factor B; spinal cord-derived growth factor-B
UniProt Protein Name
Platelet-derived growth factor D
UniProt Synonym Protein Names
Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B
UniProt Synonym Gene Names
IEGF; SCDGFB; PDGF-D; SCDGF-B; PDGFD latent form; PDGFD receptor-binding form [Similar Products]
UniProt Entry Name
PDGFD_HUMAN
NCBI Summary for PDGF-D
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PDGF-D
PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: Golgi membrane; endoplasmic reticulum lumen; extracellular region
Molecular Function: growth factor activity; platelet-derived growth factor receptor binding
Biological Process: positive regulation of cell division; multicellular organismal development; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation
Research Articles on PDGF-D
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Products associated with PDGF-D elisa kit
Pathways associated with PDGF-D elisa kit
Diseases associated with PDGF-D elisa kit
Organs/Tissues associated with PDGF-D elisa kit
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