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PAI-1 elisa kit :: Rat Plasminogen Activator Inhibitor 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS761315
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $415 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plasminogen Activator Inhibitor 1 (PAI-1), ELISA Kit

★Popular Item★
 Also Known As   

Rat Plasminogen Activator Inhibitor 1 ELISA Kit

 Product Synonym Names    Serpine1/PAI-1/PAI1/SERPINE1/Nexin/PLANH1/Endothelial plasminogen activator inhibitor/PAISerpin E1/PLANH1/plasminogen activator inhibitor 1/serine (or cysteine) proteinase inhibitor; clade E (nexin; plasminogenactivator inhibitor type 1); member 1/serpin peptidase inhibitor; clade E (nexin; plasminogen activator inhibitortype 1); member 1
 Product Gene Name   

PAI-1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS761315 QC Report    QC Report PDF
 OMIM    173360
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of PAI-1 . No significant cross-reactivity or interference between PAI-1 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids.
 Assay Type    Sandwich ELISA, Double Antibody
 Detection Range    0.313-20ng/ml
 Sensitivity    0.188ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level PAI- 1 were tested 20 times on one plate, respectively. Intra-Assay: CV<8%
 Inter-assay Precision    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level PAI- 1 were tested on 3 different plates, 8 replicates in each plate. CV (%) = SD/meanX100. Inter-Assay: CV<10%
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 Preparation and Storage    Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PAI-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PAI-1 purchase    MBS761315 is a ready-to-use microwell, strip plate Sandwich, Double Antibody ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Plasminogen Activator Inhibitor 1 (PAI-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.313-20ng/ml in biological research samples containing PAI-1, with an estimated sensitivity of 0.188ng/ml. The ELISA analytical biochemical technique of the MBS761315 kit is based on PAI-1 antibody-PAI-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PAI-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PAI-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Typical Testing Data/Standard Curve (for reference only) of PAI-1 elisa kit    PAI-1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS761315. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PAI-1. It may not necessarily be applicable to this product.
 NCBI GI #    10835159
 NCBI GeneID    5054
 NCBI Accession #    NP_000593.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000602.4 [Other Products]
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 UniProt Secondary Accession #    B7Z4S0; F8WD53 [Other Products]
 UniProt Related Accession #    P05121 [Other Products]
 Molecular Weight    43,404 Da
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 NCBI Official Full Name    plasminogen activator inhibitor 1
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 NCBI Official Symbol    SERPINE1 [Similar Products]
 NCBI Official Synonym Symbols   
PAI; PAI1; PAI-1; PLANH1
[Similar Products]
 NCBI Protein Information    plasminogen activator inhibitor 1
 UniProt Protein Name    Plasminogen activator inhibitor 1
 UniProt Synonym Protein Names   
Endothelial plasminogen activator inhibitor; Serpin E1
 Protein Family    Plasminogen activator inhibitor
 UniProt Gene Name    SERPINE1 [Similar Products]
 UniProt Synonym Gene Names    PAI1; PLANH1; PAI; PAI-1 [Similar Products]
 UniProt Entry Name    PAI1_HUMAN
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 NCBI Summary for PAI-1    This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for PAI-1    SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane

Molecular Function: protease binding; protein binding; receptor binding; serine-type endopeptidase inhibitor activity

Biological Process: angiogenesis; blood coagulation; chronological cell aging; circadian rhythm; defense response to Gram-negative bacterium; extracellular matrix organization and biogenesis; fibrinolysis; gene expression; negative regulation of blood coagulation; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; negative regulation of fibrinolysis; negative regulation of smooth muscle cell migration; placenta development; platelet activation; platelet degranulation; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of inflammatory response; positive regulation of interleukin-8 production; positive regulation of receptor-mediated endocytosis; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of receptor activity; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway

Disease: Plasminogen Activator Inhibitor-1 Deficiency
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 Research Articles on PAI-1    1. High cytoplasmic expression of PAI-1 is associated with cells of rectal cancer and metastases of perienteric lymph nodes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAI-1 elisa kitPathways associated with PAI-1 elisa kit
 Reference Product  PubMed Publications
 TGFB1 elisa kit  >55 publications with PAI-1 and TGFB1
 PLAUR elisa kit  >25 publications with PAI-1 and PLAUR
 SMAD3 elisa kit  >25 publications with PAI-1 and SMAD3
 TP53 elisa kit  >18 publications with PAI-1 and TP53
 PLAU elisa kit  >12 publications with PAI-1 and PLAU
 PLAT elisa kit  >8 publications with PAI-1 and PLAT
 SMAD4 elisa kit  >7 publications with PAI-1 and SMAD4
 VTN elisa kit  >1 publications with PAI-1 and VTN
 PLG elisa kit  >1 publications with PAI-1 and PLG
 Products by Pathway  Pathway Diagram
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 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with PAI-1 elisa kitOrgans/Tissues associated with PAI-1 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >307 publications with PAI-1 and Cardiovascular Diseases
 Inflammation Antibodies  >152 publications with PAI-1 and Inflammation
 Thrombosis Antibodies  >122 publications with PAI-1 and Thrombosis
 Obesity Antibodies  >91 publications with PAI-1 and Obesity
 Heart Diseases Antibodies  >83 publications with PAI-1 and Heart Diseases
 Necrosis Antibodies  >81 publications with PAI-1 and Necrosis
 Fibrosis Antibodies  >79 publications with PAI-1 and Fibrosis
 Atherosclerosis Antibodies  >79 publications with PAI-1 and Atherosclerosis
 Nervous System Diseases Antibodies  >66 publications with PAI-1 and Nervous System Diseases
 Hypertension Antibodies  >47 publications with PAI-1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >475 publications with PAI-1 and Blood
 Vascular Antibodies  >221 publications with PAI-1 and Vascular
 Lung Antibodies  >63 publications with PAI-1 and Lung
 Connective Tissue Antibodies  >60 publications with PAI-1 and Connective Tissue
 Heart Antibodies  >59 publications with PAI-1 and Heart
 Liver Antibodies  >58 publications with PAI-1 and Liver
 Kidney Antibodies  >47 publications with PAI-1 and Kidney
 Adipose Tissue Antibodies  >44 publications with PAI-1 and Adipose Tissue
 Muscle Antibodies  >43 publications with PAI-1 and Muscle
 Brain Antibodies  >41 publications with PAI-1 and Brain
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