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PARP elisa kit :: Rat Poly-Adp-Ribose Polymerase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS025075 PARP elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Poly-Adp-Ribose Polymerase (PARP), ELISA Kit

 Also Known As   

Rat Poly-Adp-Ribose Polymerase ELISA Kit

 Product Gene Name   

PARP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    173870
 3D Structure    ModBase 3D Structure for P09874
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 Species Reactivity    Rat
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
 Assay Type    Sandwich
 Detection Range    0.625ng/ml-20ng/ml.
 Sensitivity    0.1ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PARP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PARP purchase    MBS025075 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Poly-Adp-Ribose Polymerase (PARP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625ng/ml-20ng/ml in biological research samples containing PARP, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS025075 kit is based on PARP antibody-PARP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PARP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PARP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PARP elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PARP1 (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS025075. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PARP. It may not necessarily be applicable to this product.
 NCBI GI #    156523968
 NCBI GeneID    142
 NCBI Accession #    NP_001609.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001618.3 [Other Products]
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 UniProt Primary Accession #    P09874 [Other Products]
 UniProt Secondary Accession #    Q8IUZ9; B1ANJ4 [Other Products]
 UniProt Related Accession #    P09874 [Other Products]
 Molecular Weight    113,084 Da
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 NCBI Official Full Name    poly
 NCBI Official Synonym Full Names    poly (ADP-ribose) polymerase 1
 NCBI Official Symbol    PARP1 [Similar Products]
 NCBI Official Synonym Symbols   
PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
[Similar Products]
 NCBI Protein Information    poly [ADP-ribose] polymerase 1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
 UniProt Protein Name    Poly [ADP-ribose] polymerase 1
 UniProt Synonym Protein Names   
ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1
 UniProt Gene Name    PARP1 [Similar Products]
 UniProt Synonym Gene Names    ADPRT; PPOL; PARP-1; ARTD1; ADPRT 1 [Similar Products]
 UniProt Entry Name    PARP1_HUMAN
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 NCBI Summary for PARP    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PARP    PARP1: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423. Interacts (when poly-ADP- ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK.

Protein type: Nuclear envelope; Transferase; DNA repair, damage; Nucleolus; EC 2.4.2.30; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q41-q42

Cellular Component: nucleoplasm; transcription factor complex; membrane; nucleolus; nuclear envelope; nucleus

Molecular Function: identical protein binding; protein binding; enzyme binding; DNA binding; zinc ion binding; protein N-terminus binding; protein kinase binding; transcription factor binding; NAD binding; NAD+ ADP-ribosyltransferase activity

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; macrophage differentiation; transcription, DNA-dependent; DNA damage response, detection of DNA damage; negative regulation of transcription from RNA polymerase II promoter; DNA repair; protein autoprocessing; protein amino acid ADP-ribosylation; cellular response to insulin stimulus; base-excision repair; transforming growth factor beta receptor signaling pathway; double-strand break repair; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of growth rate; telomere maintenance
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 Research Articles on PARP    1. This study demonstrates a critical role of PARP1 in mediating smooth muscle cell loss in patients with progeria and elucidates a molecular pathway underlying the progressive SMC loss in progeria.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PARP elisa kitPathways associated with PARP elisa kit
 Reference Product  PubMed Publications
 CASP3 elisa kit  >267 publications with PARP and CASP3
 XRCC1 elisa kit  >80 publications with PARP and XRCC1
 CASP7 elisa kit  >34 publications with PARP and CASP7
 TP53 elisa kit  >32 publications with PARP and TP53
 CDKN1A elisa kit  >26 publications with PARP and CDKN1A
 PCNA elisa kit  >25 publications with PARP and PCNA
 PRKDC elisa kit  >18 publications with PARP and PRKDC
 RELA elisa kit  >14 publications with PARP and RELA
 XRCC5 elisa kit  >5 publications with PARP and XRCC5
 XRCC6 elisa kit  >3 publications with PARP and XRCC6
 Products by Pathway  Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
Diseases associated with PARP elisa kitOrgans/Tissues associated with PARP elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >563 publications with PARP and Neoplasms
 Breast Neoplasms Antibodies  >152 publications with PARP and Breast Neoplasms
 Necrosis Antibodies  >146 publications with PARP and Necrosis
 Nervous System Diseases Antibodies  >97 publications with PARP and Nervous System Diseases
 Inflammation Antibodies  >93 publications with PARP and Inflammation
 Lung Neoplasms Antibodies  >53 publications with PARP and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >49 publications with PARP and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >46 publications with PARP and Neoplasms, Experimental
 Liver Diseases Antibodies  >34 publications with PARP and Liver Diseases
 Prostatic Neoplasms Antibodies  >28 publications with PARP and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >135 publications with PARP and Blood
 Brain Antibodies  >100 publications with PARP and Brain
 Lung Antibodies  >96 publications with PARP and Lung
 Liver Antibodies  >63 publications with PARP and Liver
 Vascular Antibodies  >47 publications with PARP and Vascular
 Prostate Antibodies  >40 publications with PARP and Prostate
 Skin Antibodies  >39 publications with PARP and Skin
 Kidney Antibodies  >38 publications with PARP and Kidney
 Bone Antibodies  >28 publications with PARP and Bone
 Heart Antibodies  >28 publications with PARP and Heart
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