Q63921
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,032 Da
NCBI Official Full Name
Prostaglandin G/H synthase 1
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1
NCBI Official Synonym Symbols
Cox1; Cox3; Cox-1; Cox-3; Pghs-1 [Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Synonym Protein Names
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
UniProt Synonym Gene Names
NCBI Summary for PTGS1
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
UniProt Comments for PTGS1
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Research Articles on PTGS1
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Products associated with PTGS1 elisa kit
Pathways associated with PTGS1 elisa kit
Organs/Tissues associated with PTGS1 elisa kit
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