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P2Y12 elisa kit :: Rat Purinergic receptor P2Y, G-protein coupled, 12 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS751174 P2Y12 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Purinergic receptor P2Y, G-protein coupled, 12 (P2Y12), ELISA Kit

 Also Known As   

Rat Purinergic receptor P2Y, G-protein coupled, 12 ELISA Kit

 Product Gene Name   

P2Y12 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 609821
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 Species Reactivity    Rat
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    10-250ng/mL
 Sensitivity    0.1ng/ml
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of P2Y12 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for P2Y12 purchase    MBS751174 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Purinergic receptor P2Y, G-protein coupled, 12 (P2Y12) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10-250ng/mL in biological research samples containing P2Y12, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS751174 kit is based on P2Y12 antibody-P2Y12 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect P2Y12 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, P2Y12. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for P2Y12. It may not necessarily be applicable to this product.
 NCBI GI #    17389767
 NCBI GeneID    64805
 NCBI Accession #    AAH17898.1 [Other Products]
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 UniProt Secondary Accession #    Q546J7; D3DNJ5 [Other Products]
 UniProt Related Accession #    Q9H244 [Other Products]
 Molecular Weight    39,439 Da
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 NCBI Official Full Name    Purinergic receptor P2Y, G-protein coupled, 12
 NCBI Official Synonym Full Names    purinergic receptor P2Y, G-protein coupled, 12
 NCBI Official Symbol    P2RY12 [Similar Products]
 NCBI Official Synonym Symbols   
HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
[Similar Products]
 NCBI Protein Information    P2Y purinoceptor 12; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-protein coupled receptor
 UniProt Protein Name    P2Y purinoceptor 12
 UniProt Synonym Protein Names   
ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999
 UniProt Gene Name    P2RY12 [Similar Products]
 UniProt Synonym Gene Names    HORK3; P2Y12; ADPG-R; P2Y(ADP) [Similar Products]
 UniProt Entry Name    P2Y12_HUMAN
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 NCBI Summary for P2Y12    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
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 UniProt Comments for P2Y12    P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: cell surface; mitochondrion; integral to plasma membrane; basal plasma membrane; plasma membrane; intrinsic to membrane; caveola; external side of plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; adenosine receptor activity, G-protein coupled; platelet ADP receptor activity

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; negative regulation of cell differentiation; cell projection organization and biogenesis; hemostasis; protein kinase B signaling cascade; positive regulation of ion transport; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of calcium ion transport; blood coagulation; adenosine receptor signaling pathway; positive regulation of GTPase activity

Disease: Bleeding Disorder, Platelet-type, 8
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 Research Articles on P2Y12    1. P2Y1 and P2Y12 genes were polymorphic in a Korean population; 3 intronic P2Y12 polymorphisms (i-139C>T, i-744T>C, i-801insA) were in complete linkage disequilibrium but not with the c.52C>T polymorphism; platelet aggregation in response to ADP associated with c.52C>T polymorphism but not with the 3 intronic polymorphisms or the P2Y1 c.1622A>T polymorphism
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with P2Y12 elisa kitPathways associated with P2Y12 elisa kit
 Reference Product  PubMed Publications
 ADRA2A elisa kit  >9 publications with P2Y12 and ADRA2A
 P2RY13 elisa kit  >8 publications with P2Y12 and P2RY13
 P2RY14 elisa kit  >1 publications with P2Y12 and P2RY14
 GNAI2 elisa kit  >1 publications with P2Y12 and GNAI2
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 12 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 12 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Nucleotide-like (purinergic) Receptors Pathway antibodies  Nucleotide-like (purinergic) Receptors Pathway Diagram
 P2Y Receptors Pathway antibodies  P2Y Receptors Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
Diseases associated with P2Y12 elisa kitOrgans/Tissues associated with P2Y12 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >289 publications with P2Y12 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >261 publications with P2Y12 and Vascular Diseases
 Myocardial Ischemia Antibodies  >195 publications with P2Y12 and Myocardial Ischemia
 Thrombosis Antibodies  >169 publications with P2Y12 and Thrombosis
 Coronary Disease Antibodies  >142 publications with P2Y12 and Coronary Disease
 Embolism and Thrombosis Antibodies  >100 publications with P2Y12 and Embolism and Thrombosis
 Coronary Artery Disease Antibodies  >91 publications with P2Y12 and Coronary Artery Disease
 Coronary Thrombosis Antibodies  >85 publications with P2Y12 and Coronary Thrombosis
 Myocardial Infarction Antibodies  >74 publications with P2Y12 and Myocardial Infarction
 Acute Coronary Syndrome Antibodies  >73 publications with P2Y12 and Acute Coronary Syndrome
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >63 publications with P2Y12 and Heart
 Brain Antibodies  >34 publications with P2Y12 and Brain
 Muscle Antibodies  >15 publications with P2Y12 and Muscle
 Kidney Antibodies  >15 publications with P2Y12 and Kidney
 Ganglia Antibodies  >3 publications with P2Y12 and Ganglia
 Eye Antibodies  >2 publications with P2Y12 and Eye
 Connective Tissue Antibodies  >2 publications with P2Y12 and Connective Tissue
 Trachea Antibodies  >1 publications with P2Y12 and Trachea
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