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REST elisa kit :: Rat RE1-silencing transcription factor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9332070 REST elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RE1-silencing transcription factor (REST), ELISA Kit

★Popular Item★
 Also Known As   

Rat RE1-silencing transcription factor, REST ELISA Kit

 Product Synonym Names    Rat RE1-silencing transcription factor (REST) ELISA kit; NRSF; XBR; neuron restrictive silencer factor; repressor binding to the X2 box; RE1-silencing transcription factor
 Product Gene Name   

REST elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O54963
 Species Reactivity    Rat
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    undiluted original Rat body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    62.5 pg/ml - 2000 pg/mL
 Sensitivity    10 pg/mL
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of REST elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for REST purchase    MBS9332070 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the RE1-silencing transcription factor (REST) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5 pg/ml - 2000 pg/mL in biological research samples containing REST, with an estimated sensitivity of 10 pg/mL. The ELISA analytical biochemical technique of the MBS9332070 kit is based on REST antibody-REST antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect REST antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, REST. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for REST elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of REST (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9332070. Click to request current manual
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NCBI/Uniprot data below describe general gene information for REST. It may not necessarily be applicable to this product.
 NCBI GI #    13929116
 NCBI GeneID    83618
 NCBI Accession #    NP_113976.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031788.1 [Other Products]
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 UniProt Primary Accession #    O54963 [Other Products]
 UniProt Secondary Accession #    O54964 [Other Products]
 UniProt Related Accession #    O54963 [Other Products]
 Molecular Weight    117,126 Da
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 NCBI Official Full Name    RE1-silencing transcription factor
 NCBI Official Synonym Full Names    RE1-silencing transcription factor
 NCBI Official Symbol    Rest [Similar Products]
 NCBI Protein Information    RE1-silencing transcription factor; neural-restrictive silencer factor; zinc finger transcription factor REST protein
 UniProt Protein Name    RE1-silencing transcription factor
 UniProt Synonym Protein Names   
Neural-restrictive silencer factor
 Protein Family    RE1-silencing transcription factor
 UniProt Gene Name    Rest [Similar Products]
 UniProt Synonym Gene Names    Nrsf [Similar Products]
 UniProt Entry Name    REST_RAT
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 NCBI Summary for REST    represses transcription of the AMPA receptor (AMPAR) subunit GluR2 and other neural genes [RGD, Feb 2006]
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 UniProt Comments for REST    REST: a transcriptional repressor that binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells during embryonic development. Induced during ageing in human cortical and hippocampal neurons, where it represses genes that promote cell death and induces the expression of stress response genes. Protects neurons from amyloid beta- and oxidative stress-induced toxicity. The deletion of REST in the mouse brain induces age-related neurodegeneration. Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. REST activates DYRK1A transcription via a neuron-restricted silencer element in the DYRK1A promoter. Four isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; C2H2-type zinc finger protein; Cell development/differentiation

Cellular Component: protein complex; transcriptional repressor complex; chromatin; cytosol; nucleus

Molecular Function: protein binding; nucleic acid binding; DNA binding; metal ion binding; outward rectifier potassium channel activity; protein complex binding; chromatin binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of neuron differentiation; negative regulation of calcium ion-dependent exocytosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of aldosterone biosynthetic process; positive regulation of caspase activity; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of neurogenesis; negative regulation of insulin secretion
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 Research Articles on REST    1. these results demonstrate that REST, by regulating NCX1 expression, may represent a potential druggable target for the treatment of brain ischemia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with REST elisa kitPathways associated with REST elisa kit
 Reference Product  PubMed Publications
 Stmn2 elisa kit  >5 publications with REST and Stmn2
 Chrm4 elisa kit  >1 publications with REST and Chrm4
 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with REST elisa kitOrgans/Tissues associated with REST elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11961 publications with REST and Nervous System Diseases
 Neoplasms Antibodies  >6797 publications with REST and Neoplasms
 Hypertension Antibodies  >5424 publications with REST and Hypertension
 Brain Diseases Antibodies  >4159 publications with REST and Brain Diseases
 Myocardial Infarction Antibodies  >4029 publications with REST and Myocardial Infarction
 Fatigue Antibodies  >2848 publications with REST and Fatigue
 Carcinoma Antibodies  >2329 publications with REST and Carcinoma
 Congenital Abnormalities Antibodies  >2142 publications with REST and Congenital Abnormalities
 Drug Toxicity Antibodies  >1701 publications with REST and Drug Toxicity
 Liver Diseases Antibodies  >1315 publications with REST and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2178 publications with REST and Kidney
 Embryonic Tissue Antibodies  >424 publications with REST and Embryonic Tissue
 Pituitary Gland Antibodies  >209 publications with REST and Pituitary Gland
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