AAA60363.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,726 Da
NCBI Official Full Name
renin
NCBI Official Synonym Full Names
renin
NCBI Official Synonym Symbols
NCBI Protein Information
renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme
UniProt Protein Name
Renin
UniProt Synonym Protein Names
Angiotensinogenase
UniProt Entry Name
RENI_HUMAN
NCBI Summary for Renin
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
UniProt Comments for Renin
REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; EC 3.4.23.15; Protease; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: extracellular space; cytoplasm; plasma membrane; extracellular region
Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding
Biological Process: response to cAMP; hormone-mediated signaling; drinking behavior; cell maturation; renin-angiotensin regulation of aldosterone production; male gonad development; response to lipopolysaccharide; angiotensin maturation; proteolysis; cellular protein metabolic process; regulation of blood pressure; beta-amyloid metabolic process; regulation of MAPKKK cascade; mesonephros development; kidney development
Disease: Renal Tubular Dysgenesis; Hyperuricemic Nephropathy, Familial Juvenile, 2
Research Articles on Renin
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Products associated with Renin elisa kit
Pathways associated with Renin elisa kit
Diseases associated with Renin elisa kit
Organs/Tissues associated with Renin elisa kit
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