AAD25052.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,563 Da
NCBI Official Full Name
secreted frizzled-related protein 5
NCBI Official Synonym Full Names
secreted frizzled-related protein 5
NCBI Official Synonym Symbols
NCBI Protein Information
secreted frizzled-related protein 5; FRP-1b; SARP-3; sFRP-5; frizzled-related protein 1b; secreted apoptosis related protein 3; secreted apoptosis-related protein 3
UniProt Protein Name
Secreted frizzled-related protein 5
UniProt Synonym Protein Names
Frizzled-related protein 1b; FRP-1b; Secreted apoptosis-related protein 3; SARP-3
UniProt Synonym Gene Names
UniProt Entry Name
SFRP5_HUMAN
NCBI Summary for SFRP5
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
UniProt Comments for SFRP5
SFRP5: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. Belongs to the secreted frizzled-related protein (sFRP) family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component: extracellular space; integral to membrane
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity
Biological Process: negative regulation of JNK activity; negative regulation of cell proliferation; convergent extension involved in axis elongation; anatomical structure morphogenesis; negative regulation of protein kinase B signaling cascade; visual perception; apoptosis; negative regulation of transcription factor activity; establishment and/or maintenance of cell polarity; digestive tract morphogenesis; cell differentiation; signal transduction
Research Articles on SFRP5
Precautions
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Products associated with SFRP5 elisa kit
Pathways associated with SFRP5 elisa kit
Diseases associated with SFRP5 elisa kit
Organs/Tissues associated with SFRP5 elisa kit
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